Effects of Protein Blends on Muscle Protein Synthesis in Healthy Older Adults

DuPont

Status: Completed

Conditions: Muscle Synthesis

Treatments: Dietary Supplement: Positive Control (Dairy Whey Protein); Dietary Supplement: Soy Dairy Protein Blend

Study type: Interventional

Funder types: Industry

Identifiers

NCT01847261

IRB #12-226

Details and patient eligibility

About

During aging there is a tendency for muscle protein synthesis (growth) to become less efficient and the resulting consequence leads to reduced muscle mass (sarcopenia) which can affect strength and mobility. Protein consumption may be one opportunity to alleviate this problem especially when consumed in appropriate amounts following resistance training. This study is designed to determine if a soy dairy protein blend, shown to be effective in younger adults, will produce beneficial muscle protein synthesis in older healthy adults following resistance exercise.

Enrollment: 20 patients

Sex: Male

Ages: 55 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

55-70 yr olds Stable Body weight

Exclusion criteria

1. Exercise training (>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
2. Significant heart, liver, kidney, blood, respiratory disease or thyroid issues
3. Peripheral vascular disease
4. Orthopedic injury that prohibits participation in the exercise training
5. Diabetes mellitus or other untreated endocrine disease
6. Active cancer (all groups) and history of cancer
7. Acute infectious disease or history of chronic infections (e.g. TB, hepatitis, HIV, herpes)
8. Neurologic Injury or disease
9. Recent (within 6 months) treatment with anabolic steroids, or corticosteroids.
10. Alcohol or drug abuse
11. Tobacco use (smoking or chewing)
12. Malnutrition (BMI < 20 kg/m2, hypoalbuminemia, and/or hypotransferrinemia)
13. Obesity (BMI > 30 kg/m2)
14. Low hemoglobin levels (below normal values)
15. Food allergies
16. Taking dietary supplements such as green tea, omega 3 fatty acids, etc.
17. Females

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups

Soy Dairy Protein Blend

Experimental group

Description:

30 grams of Soy Dairy Protein Blend given as a single beverage following leg resistance exercise

Treatment:

Dietary Supplement: Soy Dairy Protein Blend

Positive Control (Dairy Whey Protein)

Active Comparator group

Description:

30 grams of Dairy Whey Protein will be given as a single beverage following leg resistance exercise

Treatment:

Dietary Supplement: Positive Control (Dairy Whey Protein)