Effects of Proton Pump Inhibitors on Kidney Transplant Recipients

Istanbul University

Status: Completed

Conditions: Magnesium Disorder; Transplant Dysfunction

Study type: Observational

Funder types: Other

Identifiers

NCT03123796

332

Details and patient eligibility

About

Use of proton pump inhibitors (PPIs) is quite common among renal transplant recipients and reduced kidney functions and hypomagnesemia with the use of PPIs have been reported. In this study, investigation of the effects of PPI use on the outcome of kidney transplant recipients is aimed.

Full description

Use of proton pump inhibitors (PPIs) is frequent among renal transplant recipients due to the common use of glucocorticoids in immunosuppresive regimens after transplantation. Reduced kidney functions and hypomagnesemia with the use of PPIs have been reported in various patient populations. However, few studies examined the effects of PPIs on kidney transplant recipients. Therefore, the aim of this study is to investigate the effects of PPI and/or histamine H2 receptor antagonist use on serum magnesium levels, allograft functions and survival in kidney transplant recipients.

Enrollment: 300 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Kidney transplant recipients who used only proton pump inhibitors and did not use histamine H2 receptor antagonists (Only PPI).
• Kidney transplant recipients who used histamine H2 receptor antagonists and did not use proton pump inhibitors (Only H2RA).
• Kidney transplant recipients who used both proton pump inhibitors and histamine H2 receptor antagonists (PPI and H2RA).
• Kidney transplant recipients who used neither proton pump inhibitors nor histamine H2 receptor antagonists (No Acid Suppressive Treatment).

Exclusion criteria

• Patients who are unwilling or unable to consent.

Trial design

300 participants in 4 patient groups

Only PPI

Description:

Kidney transplant recipients who used only proton pump inhibitors and did not use histamine H2 receptor antagonists.

Only H2RA

Description:

Kidney transplant recipients who used only histamine H2 receptor antagonists and did not use proton pump inhibitors.

PPI and H2RA

Description:

Kidney transplant recipients who used both proton pump inhibitors and histamine H2 receptor antagonists.

No Acid Suppressive Treatment

Description:

Kidney transplant recipients who used neither proton pump inhibitors nor histamine H2 receptor antagonists.