Effects of Radiofrequency Ablation of Posterior Nasal Nerves on Inflammatory Cytokines, Peak Nasal Inspiratory Flow, and Nasal Blood Flow in Patients With Chronic Rhinitis

The University of Texas System (UT)

Status: Completed

Conditions: Chronic Rhinitis

Treatments: Device: Radiofrequency ablation (RFA)

Study type: Interventional

Funder types: Other

Identifiers

NCT05648565

HSC-MS-22-0899

Details and patient eligibility

About

The purpose of this study is to assess the effectiveness of radiofrequency ablation (RFA) of the posterior nasal nerve (PNN) in chronic rhinitis (CR) patients by comparing patient reflective total nasal symptom score (rTNSS) and nasal obstruction symptom evaluation (NOSE) , peak nasal inspiratory flow (PNIF) , and levels of Type 2 cytokines pre- and post-procedure.

Enrollment: 17 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic rhinitis symptoms for at least 6 months (rhinorrhea, congestion, post-nasal drip)
• poor response to medical management that was attempted for at least 4 weeks
• a rTNSS score ≥6, as well as ≥2 for rhinorrhea, and ≥1 for congestion.

Exclusion criteria

• active sinusitis
• rhinitis medicamentosa
• recurrent and ongoing epistaxis
• immunodeficiency as defined by an illness or a history of sinus surgery.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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17 participants in 1 patient group

Radiofrequency ablation (RFA)

Experimental group

Treatment:

Device: Radiofrequency ablation (RFA)