Effects of Red Blood Cells Transfusion on Renal Blood Flow

Università degli Studi di Ferrara

Status: Completed

Conditions: Anemia; Acute Kidney Injury; Fluid Overload; Transfusion-Associated Circulatory Overload

Treatments: Other: Crystalloids infusion; Other: Transfusion

Study type: Observational

Funder types: Other

Identifiers

NCT04194047

RRIRBC

Details and patient eligibility

About

The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. It is associated with the occurrence of acute kidney injury (AKI). Many parameters have been described as influential on the values of renal RI. Red blood cell (RBC) transfusion were shown to be able to increase renal oxygenation in animal model, whereas crystalloid resuscitation did not. We sought to describe the different effect of crystalloids infusion and RBC transfusion on renal blood flow, as evaluated with doppler ultrasound

Enrollment: 33 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 and < 90
• Hemoglobin ≥7 and ≤ 10 g/dl

Exclusion criteria

• Ultrasound RRI evaluation non available
• Patients with arrhythmia
• Pregnancy
• Refusal to give consent
• History of renal transplantation
• Central venous access in superior vena cava not available Critical active bleeding

Trial design

33 participants in 3 patient groups

RBC group

Description:

Patients who received RBC transfusion

Treatment:

Other: Transfusion

crystalloids group

Description:

Patients who received fluid resuscitation with crystalloids

Treatment:

Other: Crystalloids infusion

control group

Description:

Patients not receiving RBC nor crystalloids