Effects of Regional Nerve Block on Cancer Recurrence

Luo Foquan

Status: Unknown

Conditions: Cancer Patient

Treatments: Other: peripheral Nerve block; Other: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT03134430

LFoquan

Details and patient eligibility

About

It has been reported local anesthetics could inhibit tumor cell proliferation, metastasis and invasion ability，but it is still lack of clinical evidence. Our study aims to explore the effects of regional nerve block on cancer recurrence and the mechanism.

Full description

1. To study the effects of TAP block under ultrasound guide on the recurrence of gastric carcinoma, colon cancer, rectal carcinoma and liver cancer and the underlying mechanisms.
2. To clarify the effects of Lateral thoracic nerve block under ultrasound guide on the recurrence of lung cancer and the underlying mechanisms.

Enrollment: 400 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with primary cancer undergoing elective surgery under general anesthesia

Exclusion criteria

• Disagree to participate，drop out,lose track, infectious abdominal wall，abnormal puncture point，coagulation dysfunction，allergy of local anesthetic ，immune disease,cancer metastasis,mental disease, acute and chronic infectious disease or other severe disease.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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400 participants in 2 patient groups, including a placebo group

Normal saline

Placebo Comparator group

Description:

equal volume of normal saline as treatment group

Treatment:

Other: Normal saline

peripheral Nerve block

Active Comparator group

Description:

0.35% ropivacaine and 0.5% lidocaine in normal saline

Treatment:

Other: peripheral Nerve block