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Effects of Regular Submaximal Exercise on Asthma Control and Quality of Life in Patients With Persistent Symptoms

U

University of Liege

Status

Unknown

Conditions

Chronic Asthma

Treatments

Other: exercises

Study type

Interventional

Funder types

Other

Identifiers

NCT04395937
B707202042981

Details and patient eligibility

About

The effects of regular exercise on asthma control has not yet been well demonstrated.

The aim of this study is to investigate the impact of submaximal physical exercise on quality of life, on symptomatic control, and on bronchial and systemic inflammatory markers in patients with persistant asthma.

Full description

While it is well known that intense physical exercise can generate bronchospasm and limit exercise performance, it recently appeared that regular physical exercise practiced aerobically could improve the clinical status of asthmatic patients.

The investigators are planning a 12-week randomized controlled study to assess the effect of regular aerobic exercise on quality of life, asthma control, bronchial hyperresponsiveness and bronchial and systemic inflammation in patients with persistent asthma

The hypothesis is that regular physical exercise increases control and quality of life and reduces inflammation and bronchial hyperresponsiveness compared to simple physiotherapy sessions.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • asthmatic patient
  • aged 18- 90 years
  • ACQ > 1.5
  • stable background treatment comprising at least one inhaled corticosteroid or an anti-leukotriene

Exclusion criteria

  • IMC > 35
  • severe osteoarthritis of the knees and hips
  • unstable angor
  • Severe uncontrolled hypertension

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

100 participants in 3 patient groups

respiratory physiotherapy
Active Comparator group
Description:
exercises to improve the way of breathing
Treatment:
Other: exercises
respiratory physiotherapy and physical exercises
Experimental group
Description:
intensity determined by the VO2max measured during ergospirometric measure
Treatment:
Other: exercises
control group
No Intervention group

Trial contacts and locations

1

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Central trial contact

Stephanie Ziant

Data sourced from clinicaltrials.gov

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