Effects of Regular Submaximal Exercise on Asthma Control and Quality of Life in Patients With Persistent Symptoms

University of Liege

Status: Unknown

Conditions: Chronic Asthma

Treatments: Other: exercises

Study type: Interventional

Funder types: Other

Identifiers

NCT04395937

B707202042981

Details and patient eligibility

About

The effects of regular exercise on asthma control has not yet been well demonstrated.

The aim of this study is to investigate the impact of submaximal physical exercise on quality of life, on symptomatic control, and on bronchial and systemic inflammatory markers in patients with persistant asthma.

Full description

While it is well known that intense physical exercise can generate bronchospasm and limit exercise performance, it recently appeared that regular physical exercise practiced aerobically could improve the clinical status of asthmatic patients.

The investigators are planning a 12-week randomized controlled study to assess the effect of regular aerobic exercise on quality of life, asthma control, bronchial hyperresponsiveness and bronchial and systemic inflammation in patients with persistent asthma

The hypothesis is that regular physical exercise increases control and quality of life and reduces inflammation and bronchial hyperresponsiveness compared to simple physiotherapy sessions.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• asthmatic patient
• aged 18- 90 years
• ACQ > 1.5
• stable background treatment comprising at least one inhaled corticosteroid or an anti-leukotriene

Exclusion criteria

• IMC > 35
• severe osteoarthritis of the knees and hips
• unstable angor
• Severe uncontrolled hypertension

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 3 patient groups

respiratory physiotherapy

Active Comparator group

Description:

exercises to improve the way of breathing

Treatment:

Other: exercises

respiratory physiotherapy and physical exercises

Experimental group

Description:

intensity determined by the VO2max measured during ergospirometric measure

Treatment:

Other: exercises

control group

No Intervention group