Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers

Medical University of Gdansk

Status: Unknown

Conditions: Acute Kidney Injury

Treatments: Dietary Supplement: Fructose/glucose/xylitol/saccharose

Study type: Interventional

Funder types: Other

Identifiers

NCT04310514

04-0532/09/776

Details and patient eligibility

About

Rehydration during and after physical exercise is essential to avoid acute kidney injury.

Soft drinks are commonly used during exercise. High intake of carbohydrates is leading to obesity and metabolic disorders. Fructose intake is leading to uric acid abnormalities and kidney injury.

30 healthy soccer players will be studied. During four training sessions subjects will intake 500 ml 7% soft drinks containing glucose, fructose, saccharose or xylitol.

Changes in acute kidney injury markers, markers of kidney tubular function as well as changes in CRP, glucose, cholesterol and uric acid levels will be studied..

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age above 18 years
• well-trained soccer players
• informed consent

Exclusion criteria

• chronic diseases, especially kidney problems
• sigificant changes in urinalysis
• creatinine level above normal values

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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30 participants in 4 patient groups

Experimental: glucose - fructose - xylitol - saccharose

Active Comparator group

Description:

* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)

Treatment:

Dietary Supplement: Fructose/glucose/xylitol/saccharose

Experimental: fructose - glucose - saccharose - xylitol

Active Comparator group

Description:

* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)

Treatment:

Dietary Supplement: Fructose/glucose/xylitol/saccharose

Experimental: xylitol - saccharose - glucose - fructose

Active Comparator group

Description:

* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)

Treatment:

Dietary Supplement: Fructose/glucose/xylitol/saccharose

Experimental: saccharose - xylitol - fructose - glucose

Active Comparator group

Description:

* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)

Treatment:

Dietary Supplement: Fructose/glucose/xylitol/saccharose