Effects of Remimazolam on the Intraoperative Hemodynamics in Bypass Surgery

Seoul National University

Status: Enrolling

Conditions: Intraoperative Hypotension

Treatments: Drug: Remimazolam; Drug: Balanced Anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT05557253

Bypass-RMDZ

Details and patient eligibility

About

This study is a randomized, controlled trial. A total of 72 patients will be randomized to receive remimazolam anesthesia or balanced anesthesia (propofol + desflurane) during extracranial-intracranial bypass surgery.

Enrollment: 72 estimated patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who undergo elective extracranial-intracranial bypass surgery
• American Society of Anesthesiologists grade 1,2,3
• Age > 18 years old

Exclusion criteria

• Refuse to participate to the study
• American Society of Anesthesiologists grade 4
• Body Mass Index < 18.5 kg/m2 or > 35 kg/m2
• Allergic history of benzodiazepine
• Pregnant
• Acute narrow-angle glaucoma
• Shock or Coma
• Acute alcohol addicted
• Obstructive sleep apnea
• dependency on alcohol or drug
• Severe acute respiratory insufficiency
• Hypersensitivity to Dextran 40

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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72 participants in 2 patient groups

remimazolam group

Experimental group

Description:

General anesthesia is induced and maintained with remimazolam.

Treatment:

Drug: Remimazolam

balanced group

Active Comparator group

Description:

General anesthesia is induced with propofol and maintained with desflurane.

Treatment:

Drug: Balanced Anesthesia