Effects of Repeated Transcranial Magnetic Stimulation (rTMS) on the Treatment of Cocaine Addicted Patients (TMSCOCDEPEND)

University of Sao Paulo General Hospital

Status and phase: Unknown; Phase 2

Conditions: Transcranial Magnetic Stimilation; Treatment; Cocaine Addiction

Treatments: Procedure: Transcranial Magnetic Stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT01259362

PLRIBEIRO1

Details and patient eligibility

About

Cocaine addiction is a serious disease. Nowadays we still have no efficient method reducing craving and extending the abstinence period of this patients during treatment.

The aim of this study is to evaluate reduction if craving and other parameters related to addiction within this group of patients through a treatment with transcranial magnetic stimulation.

Full description

Patients are going to submitted do a course of rTMS of one month, each session up to 15 minutes.

After the rTMS they are going to be offered cognitive therapy to prevent relapse.

The area stimulated is the dorso-lateral prefrontal cortex. This technique was employed in previous studies and the risks are insignificant.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Minimum age of 18
• Maximum age of 40
• Diagnostic of Cocaine addiction
• Willingly participate the study

Exclusion criteria

• Metallic Cerebral Implant
• History of Severe Brain trauma or injury
• Organic Brain Disease
• Severe Somatic Disease
• History of other actual or past psychiatric diagnostics

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Transcranial Magnetic Stimulation

Active Comparator group

Description:

Cocaine addicted will receive a 20 day TMSr to right dorsolateral prefrontal cortex.

Treatment:

Procedure: Transcranial Magnetic Stimulation

Procedure: Transcranial Magnetic Stimulation

Transcranial Magnetic Stimlation

Sham Comparator group

Description:

cocaine addicted will receive a 20 day sham TMSr to right dorsolateral prefrontal cortex

Treatment:

Procedure: Transcranial Magnetic Stimulation

Procedure: Transcranial Magnetic Stimulation