Effects of Repetitive Transcranial Magnetic Stimulation on Heart Rate Variability (TMSXHRV)

University of Sao Paulo

Status: Unknown

Conditions: Heart Rate Variability

Treatments: Procedure: Repetitive transcranial magnetic stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT03739489

RG-02

Details and patient eligibility

About

Repetitive transcranial magnetic stimulation is a non-invasive neuromodulation technique used to treat different neuropsychiatric disorders, such as, depression, neuropathic pain, fibromyalgia and obsessive-compulsive disorder. It is known that the heart rate variability is altered in these conditions. Therefore the focus of this research is to show the influence of rTMS on the Heart Rate Variability.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Agreed participate the protocol
• Signing the consent form
• Do not present any cardiac problems or disease

Exclusion criteria

• Trauma of Skull, epilepsy don't treated,
• Use of medications decrease the seizure threshold
• Patients in use of drugs, how cocaine and alcohol
• Neurosurgical clips, pacemakers, increased intracranial pressure (risk of sequelae after seizure)
• Pregnant or breastfeeding women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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30 participants in 3 patient groups

rTMS-PSI

Active Comparator group

Description:

Participants allocated in this arm will receive active repetitive transcranial magnetic stimulation over the posterior superior insula right.

Treatment:

Procedure: Repetitive transcranial magnetic stimulation

rTMS-M1

Active Comparator group

Description:

Participants allocated in this arm will receive active repetitive transcranial magnetic stimulation over the right primary motor cortex.

Treatment:

Procedure: Repetitive transcranial magnetic stimulation

rTMS-F3

Active Comparator group

Description:

Participants allocated in this arm will receive active repetitive transcranial magnetic stimulation over the left pre frontal dorsolateral cortex.

Treatment:

Procedure: Repetitive transcranial magnetic stimulation