Effects of Resistance and Endurance Training on Synthesis of Individual Muscle Proteins in Young and Older Adults

Mayo Clinic

Status: Completed

Conditions: Sarcopenia

Treatments: Behavioral: Endurance exercise; Behavioral: Control/Combined training; Behavioral: Resistance exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01489930

07-007689

Details and patient eligibility

About

Loss of skeletal muscle strength and skeletal muscle mass occurs with of aging. This are-related decline in skeletal muscle mass and skeletal muscle strength is a major underlying factor contributing to many of the metabolic disorders and frailty of the investigators rapidly expanding aging population. Endurance (aerobic) and resistance exercise training programs have been shown to effectively reverse the age-related decline in metabolic and contractile muscle functions. The investigators will measure synthesis rates of individual muscle proteins in 36 each of young (18-30 yrs) and 36 older (> 65 yrs) people to determine their response to 8 weeks each of endurance, resistance, combined endurance and resistance training, or placebo exercise training.

Hypotheses.

1. to measure fractional synthesis rates of multiple muscle proteins and identify those that are enhanced by an endurance exercise program
2. to determine whether changes in protein synthesis in response to endurance exercise programs are dependent on age
3. to measure fractional muscle synthesis rates of multiple muscle proteins and to identify those that are enhanced by a resistance exercise program
4. to determine whether changes in protein synthesis in response to resistance exercise programs are dependent on age

Enrollment: 67 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• 18 to 30 or >65 years
• Males and Females

Exclusion criteria

• Regular Exercise Program
• Smoking
• Cardiometabolic Disease (diabetes, cardiovascular disease, thyroid disorders)
• Drugs known to impair metabolic function (beta blockers, steroids)
• Allergies to lidocaine
• Physical disability that precludes exercise

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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67 participants in 3 patient groups

Endurance Exercise

Experimental group

Description:

Participants will perform 8-weeks of moderate intensity endurance (cycling) exercise

Treatment:

Behavioral: Endurance exercise

Resistance Exercise

Experimental group

Description:

Participants will perform 8-weeks of whole-body resistance exercise training.

Treatment:

Behavioral: Resistance exercise

Control / Combined Training

Experimental group

Description:

Participants will perform 8-weeks of no exercise, followed by an additional 8-weeks of combined endurance plus resistance exercise training.

Treatment:

Behavioral: Control/Combined training