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Effects of Resistance Training Preconditioning on Skeletal Muscle Recovery From a Period of Disuse in Young Adults

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Auburn University

Status

Not yet enrolling

Conditions

Atrophy, Disuse
Atrophy, Muscular

Treatments

Other: Resistance Training Preconditioning
Other: Control

Study type

Interventional

Funder types

Other

Identifiers

NCT05760066
MDR0823

Details and patient eligibility

About

The goal of this clinical trial is to compare the effects of resistance training (RT) preconditioning vs no training on disuse-induced atrophy and post-disuse resistance training in young healthy individuals. The main questions it aims to answer are:

  • To determine if performing RT prior to a period of disuse enhances the regain of strength, skeletal muscle size, and skeletal muscle quality while performing RT after a period of disuse.
  • To determine if performing RT prior to a period of disuse dampens the maladaptive effects of disuse on muscle size, muscle quality, and strength.
  • To determine the anabolic and proteolytic mechanisms underpinning the observed outcomes.

Participants will:

  1. Perform either 6 weeks of resistance training or maintain an untrained lifestyle
  2. Perform 2 weeks of limb immobilization induced disuse of a randomized leg
  3. Perform 6 weeks of resistance training

Researchers will compare the resistance training preconditioning condition vs the non-trained condition to see if resistance training prior to a period of disuse is beneficial during the disuse period and in the return to training period on skeletal muscle size, strength, and underpinning molecular markers.

Enrollment

24 estimated patients

Sex

All

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Between the ages of 18-30
  • Free from medical implants in lower extremity that would interfere with low-dose radiation
  • Are not allergic to ultrasound gel or Lidocaine
  • Have no or minimal experience with resistance training (less than 1 training session/week for a 1 year period)

Exclusion criteria

  • Have been exposed to medically necessary radiation in the past 12 months other than dental x-rays
  • Have known overt cardiovascular or metabolic disease
  • Have a medical condition that would contraindicate participating in an exercise program or donating a skeletal muscle biopsy (e.g. blood clotting disorder, taking blood thinners, etc.)
  • Are undergoing medical treatment for a disease that would interfere physiologically or logistically with study outcomes and/or protocols (e.g. undergoing chemotherapy and/or radiation for cancer treatment)
  • Have consumed supplemental protein, creatine, and/or agents that affect hormone status (e.g. testosterone, growth hormone boosters, etc.) within the previous 2 months.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

24 participants in 2 patient groups

Resistance Training Preconditioning (PRECON)
Experimental group
Description:
This group will perform: 1. 6 weeks of lower body focused resistance training 2. 2 weeks of locking brace-induced immobilization of a randomized leg 3. 6 weeks of lower body focused resistance training
Treatment:
Other: Resistance Training Preconditioning
Control (CTL)
Active Comparator group
Description:
This group will perform: 1. 6 weeks of activities of daily living (no training) 2. 2 weeks of locking brace-induced immobilization of a randomized leg 3. 6 weeks of lower body focused resistance training
Treatment:
Other: Control

Trial contacts and locations

0

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Central trial contact

John M Michel, MS; Michael D Roberts, PhD

Data sourced from clinicaltrials.gov

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