Effects of Resistance Training With High vs. Light-moderate Loads on Muscle-tendon Function in the Elderly

University of Castilla-La Mancha

Status: Completed

Conditions: Aging; Sarcopenia; Frail Elderly Syndrome

Treatments: Behavioral: One High Intensity resistance training session; Behavioral: Control (12 weeks); Behavioral: Light-moderate intensity resistance training (12 weeks); Behavioral: One Light-moderate intensity resistance training session; Behavioral: High Intensity resistance training (12 weeks)

Study type: Interventional

Funder types: Other

Identifiers

NCT03724461

DEP2015-69386-R

Details and patient eligibility

About

There are no unbiased studies that have analyzed the effects of resistance training with traditional, heavy versus light-moderate loads on muscle, tendon and bone in elderly people.

The purpose of the present study is to assess the effects on muscle mass and function, tendon and bone of two different training intensities, light-moderate vs. heavy load, in people older than 65 years old.

The study will be carried out with a randomized controlled design. Participants will perform single training sessions and a 12-wk dynamic resistance training program on the knee extensors with different training intensities on each leg. One leg will train with heavy loads and the other one will train with light-moderate loads, but matching the load x repetitions performed by the contralateral side.

Full description

The decline in muscle function provoked by the aging process and frailty are directly related to decreases in mobility and the ability to perform the so called "daily life activities". Resistance training is especially useful at this stage, given that it is an effective and widely applicable intervention to control and revert sarcopenia, and the deterioration of tendon and bone function. Despite of the effectiveness of heavy load resistance training, a controversy has arisen in the last years about the effects of lower load resistance training programs to achieve similar adaptations. This is because most of the studies that have compared light-moderate versus heavy load programs did not control the differences in total training load, measured as the overall mechanical work performed during the training program. Therefore, there are no unbiased studies that have analyzed the effects of resistance training with traditional, heavy versus light-moderate loads on muscle, tendon and bone in elderly people.

The purpose of the present study is to assess the effects on muscle mass and function, tendon and bone of two different training intensities, light-moderate vs. heavy load, in people older than 65 years old.

The studies will be carried out with a crossover (acute training sessions) and randomized controlled design (longitudinal training intervention). Participants will perform single training sessions with each resistance training intensity and a 12-wk dynamic resistance training program on the knee extensors with different training intensities on each leg. One leg will train with heavy loads and the other one will train with light-moderate loads, but matching the load x repetitions performed by the contralateral side. Muscle adaptations (EMG, muscle size and architecture), tendon mechanical properties, bone mineral density, blood parameters and life quality will be analyzed before and after the cessation of the training program.

Enrollment: 55 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 65 years and older,
• non-institutionalized
• passed physical examination including physical function assessment (no frailty status; SPPB >7 points)

Exclusion criteria

• Neurological, musculoskeletal, or other disorder that would preclude completing resistance training and all performance tests
• Uncontrolled hypertension, unstable or exercise-induced angina pectoris or myocardial ischemia or any other medical condition that would interfere with testing or increase one's risk of complications during exercise.
• History of regular resistance exercise during the previous 3 years
• Knee prosthesis

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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55 participants in 5 patient groups

High intensity vs Control (12 weeks)

Active Comparator group

Description:

8 weeks of baseline period plus an exercise program where one leg undergoes High Intensity resistance training (12 weeks) and the other leg is established as control.

Treatment:

Behavioral: High Intensity resistance training (12 weeks)

Behavioral: Control (12 weeks)

Light intensity vs Control (12 weeks)

Active Comparator group

Description:

8 weeks of baseline period plus an exercise program where one leg undergoes light-moderate intensity resistance training (12 weeks) and the other leg is established as control.

Treatment:

Behavioral: Light-moderate intensity resistance training (12 weeks)

Behavioral: Control (12 weeks)

High vs Light intensity (12 weeks)

Experimental group

Description:

8 weeks of baseline period plus an exercise program where one leg undergoes High Intensity resistance training (12 weeks) and the other leg undergoes light-moderate intensity resistance training.

Treatment:

Behavioral: High Intensity resistance training (12 weeks)

Behavioral: Light-moderate intensity resistance training (12 weeks)

High intensity (Acute)

Experimental group

Description:

Analysis of the effects of one High Intensity resistance training session, with a crossover design.

Treatment:

Behavioral: One High Intensity resistance training session

Light intensity (Acute)

Experimental group

Description:

Analysis of the effects of one Light-moderate Intensity resistance training session, with a crossover design.

Treatment:

Behavioral: One Light-moderate intensity resistance training session