Effects of Respiratory Rehabilitation on ICU Patients

Chinese PLA General Hospital (301 Hospital)

Status: Unknown

Conditions: Rehabilitation; ICU Acquired Weakness

Treatments: Behavioral: pulmonary rehabilitation

Study type: Interventional

Funder types: Other

Identifiers

NCT04368286

S2018-212-01

Details and patient eligibility

About

Effects of respiratory rehabilitation on patients after extubation

Full description

The purpose of this study is to evaluate whether sequential treatment with high-flow humidification therapy apparatus can improve the postoperative recovery and functional status of patients with invasive mechanical ventilation in ICU after the withdrawal of the catheter.Inclusion criteria: age 18-95;The hemodynamics were stable, that is, 50 < heart rate less than 120 beats/min, 90 < systolic blood pressure < 200mmHg, 55 < mean arterial pressure < 120mmHg.Do not increase the dose of vasopressor for at least 2 hours;Intracranial pressure was stable and there was no seizure within 24 hours.The breathing condition was stable, that is, the oxygen satiety of the patient's finger vein was ≥88%, and the breathing frequency was >10 and< 35 times/min.Exclusion criteria: pregnancy;Acute myocardial infarction.A total of 50 patients who are sequentially treated with high-flow humidification therapy apparatus after extubation in ICU are randomly assigned. The experimental group receive respiratory rehabilitation therapy, while the control group only receive routine medical treatment. All the enrolled patients underwent rehabilitation evaluation and bedside diaphragmatic ultrasound measurement.This study was approved by the Ethics Committee of the CPLA General Hospital (project No.2018-212-01). The following clinical datas were recorded for all patients through the unified database software: The rehabilitation program was formulated according to the cluster management strategy of ABCDEF and the six-step method of early activities.All of the patients in monitoring vital signs, every day at hospital group and all peripheral muscle MRC assessment, 30 s sit stand trial, modified Barthel index, Borg dyspnea score, arterial blood gas analysis, diaphragm ultrasonic monitoring by the bed, finally the experimental process on the patients whether using noninvasive ventilator, whether for endotracheal intubation again, whether to have new complications (pressure sores, aspiration, thrombosis, etc.) and the patients bed time statistics for the first time. Statistical analyses were conducted by SPSS 21.0 and a two-tailed P < 0.05 was considered significant.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged above 18
• The hemodynamics are stable
• 50 < heart rate less than 120 beats/min
• 90 < systolic blood pressure < 200mmHg
• 55 < mean arterial pressure < 120mmHg
• Do not increase the dose of vasopressor for at least 2 hours
• Intracranial pressure was stable and there is no seizure within 24 hours
• The breathing condition is stable
• the oxygen satiety of the patient's finger vein is ≥88%
• 10<the breathing frequency < 35 times/min

Exclusion criteria

• Pregnancy
• Acute myocardial infarction (ami)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Rehabilitation group

Experimental group

Description:

To conduct a comprehensive pulmonary rehabilitation assessment and treatment

Treatment:

Behavioral: pulmonary rehabilitation

Conventional medical group

No Intervention group

Description:

Conventional medical treatment