Effects of ReWin(d) Supplementation on the Recovery of DOMS Induced by Acute Exercice

Natural Origins

Status and phase: Completed; Phase 2

Conditions: Muscle Soreness; Delayed-onset Muscle Soreness

Treatments: Dietary Supplement: Polyherbal supplement: ReWin(d) vs Placebo

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT03961022

Nat.Origins-ReWin(d)-2019

Details and patient eligibility

About

The study will assess the recovery and performance of young athletes suffering from muscle damage induced by physical exercise. Model by comparing the safety and efficacy of ReWin(d) supplemention during 4 weeks to placebo over 72 hours post exercice.

Full description

Double-blind, randomized, placebo controlled, parallel group, pilot safety and efficacy study.

40 healthy young male athetes were randomly assigned to the ReWin(d) or Placebo group. After 4 weeks supplementation (either 2 g daily of ReWin(d) capsules or placebo capsules). the participants were subjected to a 1 hour plyometric exercise session to induce DOMS. At 0 hours, 24 hours, 48 hours and 72 hours post exercise, the volunteers have been assessed to determine: (i) pain perception, (ii) fatigue rate, (iii) sport performance (effectiveness of a jump) and (iv) muscle damage and inflammation by I-R thermography and biomarkers

Enrollment: 40 patients

Sex: Male

Ages: 20 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• > 18 years old
• Young athletes
• Training at least 3 times per week
• Agree not to initiate any new exercise or diet programs during the entire study period
• Agree not to change their current diet or exercise program during the entire study period
• Agree not to stretch, utilize ice massage, take anti-inflammatory medications (eg, aspirin, ibuprofen), or use any other treatment for the duration of the trial.

Exclusion criteria

• Previous history of upper extremity injury or knee joint pain
• Use of anti-inflammatory medications or pain medications 1 week before the screening visit and during the study
• Daily use of dietary supplements and herbal supplements beginning at the screening visit and during the study
• Antibiotic use in past 3 months
• Chronic disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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40 participants in 2 patient groups, including a placebo group

ReWin(d)

Active Comparator group

Description:

Subjects have to take ReWin(d) capsules (3 times a day, total 2 g/day) during breakfast, lunch and diner, during 4 weeks + 3 days after acute exercice

Treatment:

Dietary Supplement: Polyherbal supplement: ReWin(d) vs Placebo

placebo

Placebo Comparator group

Description:

Subjects have to take Placebo capsules (3 times a day, total 2 g/day) during breakfast, lunch and diner, during 4 weeks + 3 days after acute exercice

Treatment:

Dietary Supplement: Polyherbal supplement: ReWin(d) vs Placebo