Effects of Rhythmic Auditory Stimulation on Movements in Individuals at Risk for Psychotic Onset and Schizophrenia Patients

Dr WANG Shumei

Status: Unknown

Conditions: Psychosis; Schizophrenia; Parkinsonism; Dyskinesias

Treatments: Behavioral: RAS for at-risk individuals; Behavioral: No RAS for schizophrenia patients; Behavioral: No RAS for at-risk individuals; Behavioral: Rhythmic auditory stimulation (RAS) for schizophrenia patients

Study type: Interventional

Funder types: Other

Identifiers

NCT04553835

HSEARS20200630002

Details and patient eligibility

About

The purpose of this research is to examine effects of movement training with the aid of rhythmic auditory stimulation (RAS) on reducing severity of dyskinesia and bradykinesia in at-risk individuals and schizophrenia patients. The investigators hypothesize that training with the aid of RAS reduced severity of bradykinesia and dyskinesia in at-risk individuals as well as in schizophrenia patients.

Enrollment: 60 estimated patients

Sex: All

Ages: 13 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

For at-risk individuals:

The inclusion criteria for at-risk individuals are:

1. A score of or above 9 in the Chinese version of the 16-item Prodromal Questionnaire (CPQ-16), or a score of or above 8.18 in the Chinese version of Community Assessment of Psychic Experiences with 15 items (CAPE-C15), or a score of or above 17 in Schizotypal Personality Questionnaire-Brief (SPQ-B);
2. A score of or above 22 in the Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) to ensure that they can understand instructions;
3. A score of or above 60 in the Chinese Version of Edinburgh Handedness Inventory to ensure that they are right-handed.
4. The age ≥ 13 years.

The inclusion criteria for healthy controls are:

1. A score below the cut-off score of CPQ-16, CAPE-C15, and SPQ-B;
2. A score of or above 22 in MoCA;
3. A score of or above 60 in the Chinese Version of Edinburgh Handedness Inventory;
4. No first-degree family members having a diagnosis of mental illnesses.
5. The age ≥ 13 years.

At-risk participants and healthy controls will be excluded if they have any neurological / musculoskeletal dysfunction that may affect their upper-limb movements.

For schizophrenia patients:

The inclusion criteria for schizophrenia patients are:

1. A diagnosis of schizophrenia without other psychiatric diseases;
2. Having stable psychotic symptoms;
3. A score of or above 22 in HK-MoCA;
4. A score of or above 60 in the Chinese Version of Edinburgh Handedness Inventory.
5. The age ≥ 18 years.

The inclusion criteria for healthy controls are:

1. A score below the cut-off score of CPQ-16, CAPE-C15, and SPQ-B;
2. A score of or above 22 in MoCA;
3. A score of or above 60 in the Chinese Version of Edinburgh Handedness Inventory;
4. No first-degree family members having a diagnosis of mental illnesses.
5. The age ≥ 18 years.

Patients and healthy controls will be excluded if they have any neurological / musculoskeletal dysfunction that may affect their upper-limb movements.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 4 patient groups

schizophrenia- RAS

Experimental group

Description:

Schizophrenia patients in the experimental group will undergo upper-limb movement training with the aid of rhythmic auditory stimulation (RAS).

Treatment:

Behavioral: Rhythmic auditory stimulation (RAS) for schizophrenia patients

schizophrenia- no RAS

Active Comparator group

Description:

Schizophrenia patients in the control group will receive upper-limb training without the aid of RAS.

Treatment:

Behavioral: No RAS for schizophrenia patients

at risk- RAS

Experimental group

Description:

At-risk individuals in the experimental group will undergo upper-limb movement training with the aid of RAS.

Treatment:

Behavioral: RAS for at-risk individuals

at risk- no RAS

Active Comparator group

Description:

At-risk individuals in the control group will receive upper-limb training without the aid of RAS.

Treatment:

Behavioral: No RAS for at-risk individuals