Effects of Roux-en-Y Gastric Bypass on Gastro-intestinal Hormone Secretion and Brain Responses Food Pictures

University of Lausanne (UNIL)

Status: Completed

Conditions: Obesity

Treatments: Other: standard test meal

Study type: Observational

Funder types: Other

Identifiers

NCT02160379

219/09

Details and patient eligibility

About

This is a cross-sectional study enrolling

• 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB)
• 11 age- and weight-matched female subjects
• 10 normal weight (Body Mass Index 19-25 kg/m2) subjects The following measurements will be performed in each participants in basal conditions (after an overnight fast) and after ingestion of a standard meal
• electroencephalographic recordings of visually evoked potential after presentation of food- or non-food pictures
• plasma concentration of metabolites (glucose, fatty acids), glucoregulatory hormones (insulin, glucagon), gastro-intestinal hormones (Gastric Inhibitory Polypeptide (GIP), Glucagon-like Peptide-1 (GLP1), ghrelin,Cholecystokinin (CCK), and bile acids Aims of this observational study are
• to evaluate the effects of RYGB on brain perception of food related visual stimulation
• to search for relationships between RYGB effects on brain responses and gastro-intestinal hormone secretion

Enrollment: 31 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• good apparent health
• gender: female
• age 18-50
• non-smoker

Exclusion criteria

• diabetes or antidiabetic medication
• consumption of more than 50g alcohol per week
• vegetarian or any special diet

Trial design

31 participants in 3 patient groups

post Roux-en-Y-gastric bypass

Description:

Formerly obese females 1-5 years after gastric bypass

Treatment:

Other: standard test meal

matched controls

Description:

non-operated females age-and weight-matched to post Roux-en-Y-gastric bypass subjects

Treatment:

Other: standard test meal

healthy young controls

Description:

non overweight (BMI between 19 and 25 kg/m2) healthy females

Treatment:

Other: standard test meal