Effects of rTMS on Corticomotor Excitability and Balance Performance in Parkinson's Disease

Chung Shan Medical University

Status: Completed

Conditions: Balance; Motor Cortex; Parkinson Disease; Excitability; Motor Skills Disorders

Treatments: Device: rTMS

Study type: Interventional

Funder types: Other

Identifiers

NCT07195773

CS2-23200

Details and patient eligibility

About

The study investigates the effects of repetitive transcranial magnetic stimulation on motor cortex excitability, balance, and motor function in patients with Parkinson's disease. Additionally, it further examines the effects of single-session low-frequency and high-frequency repetitive transcranial magnetic stimulation on motor cortex excitability.

Full description

The study investigates the effects of repetitive transcranial magnetic stimulation on motor cortex excitability, balance, and motor function in patients with Parkinson's disease. Additionally, it further examines the effects of single-session low-frequency and high-frequency repetitive transcranial magnetic stimulation on motor cortex excitability.

Enrollment: 21 patients

Sex: All

Ages: 40 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with primary Parkinson's disease
2. Age: 40-85 years
3. Hoehn and Yahr scale (H&Y scale) : I-III
4. Appropriate prescribed medication, and regular intake for more than 2 weeks
5. Can walk more than 10m with or without the use of assistive devices

Exclusion criteria

1. Any other neurological presentation (Excluding PD)
2. Any neurological surgery that would affect participation in this experiment
3. Orthopedic pathology and Cardiovascular issues
4. MMSE≦24
5. Exercise used for treatment in the last three months
6. Contraindications for transcranial magnetic stimulation (Presence of metal implants in the head and neck, a pacemaker in the chest, personal or family history of epilepsy, recent brain injury, currently taking antidepressant medication.)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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21 participants in 3 patient groups

Group A

Experimental group

Description:

Patients in this group first undergo high-frequency rTMS treatment, followed by a two-week rest period, then proceed to low-frequency rTMS after another two-week rest, and finally receive sham stimulation rTMS. rTMS high-frequency 1Hz 80%RMT rTMS low-frequency 1Hz 80%RMT rTMS sham 10HZ 20%RMT

Treatment:

Device: rTMS

Group B

Experimental group

Description:

Patients in this group first undergo low-frequency rTMS treatment, followed by a two-week rest period, then proceed to high-frequency rTMS after another two-week rest, and finally receive sham stimulation rTMS. rTMS high-frequency 1Hz 80%RMT rTMS low-frequency 1Hz 80%RMT rTMS sham 10HZ 20%RMT

Treatment:

Device: rTMS

Group C

Experimental group

Description:

Patients in this group first undergo sham stimulation rTMS treatment, followed by a two-week rest period, then proceed to high-frequency rTMS after another two-week rest, and finally receive low-frequency rTMS. rTMS high-frequency 1Hz 80%RMT rTMS low-frequency 1Hz 80%RMT rTMS sham 10HZ 20%RMT

Treatment:

Device: rTMS