Effects of Sage Extracts on Cognitive Function During Aerobic Exercise

University of Burgundy

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Sage extracts Cognivia

Study type: Interventional

Funder types: Other

Identifiers

NCT04804657

CEP2101

Details and patient eligibility

About

Extracts of sage have been reported to interact with central nervous system (CNS) mechanisms relevant to cognitive performance but, to date, no trial has clearly demonstrated the possible effects in healthy individuals in fatiguing conditions. The current study investigates the effects of this supplementation in healthy males and females versus placebo on cognition, heart rate and perceived exertion, during a fatiguing cycling exercise.

Full description

Healthy males and females will be tested in fresh and fatiguing conditions to mimic individuals at the beginning or during a competition where cognitive function are important for decision making for example. Tests will be conducted during the warm-up (fresh), during fatiguing situations (during two consecutive 10-minutes pedaling exercises) and during recovery. Tests will include a reverse digit memory test (from 3 to 7 digits), a stroop test, a simple reaction time test. Moreover, heart rate and rating of perceived exertion will be quantified.

Enrollment: 17 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index lower than 27 and waist size lower than 94 cm
• physical activity higher than 3 hours a week
• written informed consent

Exclusion criteria

• more than 12 hours training a week
• asthmatic, smokers or under medicinal drugs
• dietary supplement, sports drink, special dietary food or functional food, of any kind, liable or presented as liable to enhance physical performances

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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17 participants in 2 patient groups, including a placebo group

Sage extract

Active Comparator group

Description:

Two hours before the endurance test, participants were asked to absorb two capsules of sage extracts (600mg each - cognivia™)

Treatment:

Dietary Supplement: Sage extracts Cognivia

placebo

Placebo Comparator group

Description:

Two hours before the endurance test, participants were asked to absorb two capsules of placebo (similar appearance than active comparator).

Treatment:

Dietary Supplement: Placebo