Effects of Sage on Memory and Mental Performance in Alzheimer's Disease Patients

Oregon Health & Science University (OHSU)

Status and phase: Completed; Phase 1

Conditions: Alzheimer Disease

Treatments: Drug: Salvia officinalis (sage)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00110552

U19AT002656-03 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to determine the effectiveness of the herb sage in improving the mental function of individuals with Alzheimer's disease.

Study hypothesis: The administration of sage will improve cognitive function in patients with mild Alzheimer's disease.

Full description

The herb sage has been shown to enhance memory and mental function in healthy, young adults. However, studies assessing the herb's effectiveness in older adults with symptoms of Alzheimer's disease are limited. This study will determine the effect of sage extract on the cognitive function of patients with mild Alzheimer's disease.

This study will last 6 weeks and will comprise 4 study visits, approximately 10 days apart. Participants will be randomly assigned to receive either sage pills or no treatment during each 10-day period. The treatment assignments will be switched in 10-day intervals, so that during the course of the study, each participant will undergo two periods of sage treatment and two periods without treatment. At each study visit, participants will undergo cognitive testing, including tests to determine attention, memory, and visual cognition. Participants will also undergo an electroencephalogram (EEG) and an electrocardiogram (ECG) at each visit.

Enrollment: 111 patients

Sex: All

Ages: 50 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of mild Alzheimer's disease
• Partner, friend, child, spouse, or relative willing to accompany participants to all study visits, provide informed consent, monitor participants' pill-taking, and communicate changes in participants' health during the study

Exclusion criteria

• Significant medical illness other than Alzheimer's disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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111 participants in 2 patient groups

1

Experimental group

Description:

Sage capsules taken by mouth

Treatment:

Drug: Salvia officinalis (sage)

2

No Intervention group

Description:

No intervention, no-pill as control