Effects of Salmon Fishmeal Ex Vivo (FishMeal Ex Vivo)

University of Oslo

Status: Completed

Conditions: Inflammation; Endocrine; Obesity; Metabolic Disease

Treatments: Dietary Supplement: Whey; Dietary Supplement: Salmon fishmeal

Study type: Interventional

Funder types: Other

Identifiers

NCT04078958

2019/875/REK sør-øst B

Details and patient eligibility

About

Diabetes contributes significantly to the burden of disease in Norway and cardiovascular disease is the main cause of mortality.

Both lean and fatty fish are shown to have beneficial health effects. In addition to omega-3 fatty acids, fish contain potential health-promoting components such as taurine, vitamin D, vitamin B12, iodine, selenium and more unspecified components such as bioactive peptides. With the expected growth in the aquaculture sector, more protein-rich by-products will become available.

The overall aim of this project is to investigate physiological and molecular effects of fish protein in the form of salmon fishmeal compared to whey in a human intervention study with regard to carbohydrate- and fat metabolism, endocrine factors and inflammation.

The investigators will include healthy subjects to a randomized controlled cross over study. The subjects will receive a single, oral dose of fishmeal or whey. Blood samples are taken before (fasting) and 30 and 60 minutes after intake. The molecular effects of fishmeal and whey are investigated ex vivo. This is done by incubating human cell lines (i.e hepatocytes, adipocytes, epithelial cells) with fasting and postprandial serum from the participants.

Enrollment: 5 patients

Sex: All

Ages: 20+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Body mass index 18.5-24.9 kg/m2

Exclusion criteria

• Body mass index <18.5 or >24.9 kg/m2
• Known diabetes or high blood pressure
• Pregnancy or breast feeding
• Allergy or intolerance to dairy or fish/fish protein.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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5 participants in 2 patient groups

Salmon fishmeal

Experimental group

Description:

5 g fishmeal in capsules, single oral dose

Treatment:

Dietary Supplement: Salmon fishmeal

Whey

Active Comparator group

Description:

5 g whey in capsules, single oral dose

Treatment:

Dietary Supplement: Whey