Effects of Sea Buckthorn Oil on Dry Eye (DESB)

University of Turku

Status: Completed

Conditions: Dry Eye Syndromes

Treatments: Dietary Supplement: Sea buckthorn (Hippophaë rhamnoides) oil; Dietary Supplement: Placebo comparison

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00739713

DESB

Details and patient eligibility

About

The objective is to study the effect of sea buckthorn oil on dry eye.

Full description

The objective is to study whether regular consumption of sea buckthorn berry oil can relieve the symptoms of dry eye syndrome. The study design is a parallel randomized double-blind placebo controlled trial. The participants daily consume sea buckthorn or placebo oil for 3 months. The dry eye symptoms will be monitored during the study using a validated questionnaire. In addition clinical dry eye tests are made by an ophthalmologist three time during the study. Samples will be taken for tear film lipid and cytokine analyses. Blood samples for the analyses of inflammatory markers are also obtained. The cytokine and other inflammation marker analyses are optional. The symptoms will be monitored and clinical tests made also 4 weeks after the participants have stopped consuming the study oils.

Enrollment: 100 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Dry eye symptoms

Exclusion criteria

• Severe illness
• Anticholinergic drugs
• Smoking

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 2 patient groups, including a placebo group

SB

Experimental group

Description:

Sea buckthorn oil group

Treatment:

Dietary Supplement: Sea buckthorn (Hippophaë rhamnoides) oil

PL

Placebo Comparator group

Description:

Placebo group

Treatment:

Dietary Supplement: Placebo comparison