Effects of Sedatives on Sublingual Microcirculation of Patients With Septic Shock

Casa de Saúde São José

Status: Completed

Conditions: Shock,; Sepsis

Treatments: Drug: Sedation drug (Propofol and Midazolam)

Study type: Interventional

Funder types: Other

Identifiers

NCT01618396

CSSJ001

Details and patient eligibility

About

Previous studies have demonstrated that altered microvascular blood flow is an important marker of severe sepsis. Usually, these patients need invasive ventilatory support, frequent use of sedatives and it is unknown if these agents interfere or not on microvascular blood flow. The goal of this study was to compare effects of propofol and midazolam infusions on sublingual microcirculation of septic shock patients.

Enrollment: 16 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Septic shock patients needing mechanical ventilation in pressure or volume-controlled mode.

Exclusion criteria

• age less than 18 years,
• pregnancy,
• non-sinus rhythm, and
• contraindication of daily interruption of sedative drug,
• mainly with the use of neuromuscular blocking drugs, or
• patients with intracranial hypertension or epileptical status.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind