Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion

University of Zurich (UZH)

Status and phase: Unknown; Phase 4

Conditions: Ischemia/Reperfusion Injury

Treatments: Drug: Sevoflurane (Preconditioning)

Study type: Interventional

Funder types: Other

Identifiers

NCT00526695

17-2005

Details and patient eligibility

About

Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury.

Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation

Full description

Healthy volunteers are included in the study to investigate endothelial function and platelet activation after preconditioning by sevoflurane in subanesthetic concentrations.

Forearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.

Enrollment: 10 estimated patients

Sex: Male

Ages: 25 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria: male

• Non-smoker
• No asthma
• NPO
• Volunteer

Exclusion criteria:

• Female
• Chronic medication
• Asthma
• Smoking

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)