Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery

National and Kapodistrian University of Athens

Status: Enrolling

Conditions: Respiratory Mechanics; Intraoperative

Treatments: Drug: Sevoflurane (Volatile Anesthetic); Drug: Desflurane (volatile anesthetic)

Study type: Interventional

Funder types: Other

Identifiers

NCT07304479

705/25-07-2025

Details and patient eligibility

About

Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation. There is little literature, however, in the comparative use of sevoflurane versus desflurane anesthesia in patients undergoing abdominal robotic-assisted surgery and their effects on lung mechanics.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 87 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 to 87 years
• Undergoing elective robotic-assisted abdominal surgery
• ASA physical status I-III

Exclusion criteria

• ASA IV or V
• Emergency surgery
• Renal insufficiency
• Clinically significant respiratory disease
• Cardiomyopathy
• Uncontrolled hypertension

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

50 participants in 2 patient groups

Sevoflurane (Volatile Anesthetic)

Active Comparator group

Treatment:

Drug: Sevoflurane (Volatile Anesthetic)

Deslfurane (Volatile Anesthetic)

Active Comparator group

Treatment:

Drug: Desflurane (volatile anesthetic)