Effects of Silica and Asbestos Fibres on the Efferocytosis Capacities of Macrophages (MacFibOsis)

R

Rennes University Hospital

Status

Completed

Conditions

History of Exposure to Silica or Asbestosis
Positive Testing for ANA as a Marker of Systemic Autoimmune Diseases

Treatments

Biological: Blood sample
Biological: Blood collection

Study type

Interventional

Funder types

Other

Identifiers

NCT04473742
35RC20_8878_MacFibOsis

Details and patient eligibility

About

Evaluation of the efferocytosis capacities of blood Monocyte Derived Macrophages (MDM) from patients with a history of asbestosis or silica exposure and comparison of these capacities with those of MDM from healthy donors.

Full description

Patients with a proven history or current exposure will have 4 EDTA tubes drawn, approximately 24mL of fresh whole blood for efferocytosis assessment and : 2 x 6mL serum tubes for the assessment of Antinuclear Antibody (ANA) positivity, serum high-mobility group box 1 (HMGB1) and osteopontin for patients exposed to asbestos 1 x 6mL serum tube for serum HMGB1 and osteopontin for patients exposed to silica

Enrollment

23 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patient older than 18 Yo
  • Addressed to the department of occupational disease
  • With a history of asbestosis or silica exposure evaluated by a dedicated questionnaire and a throughout examination of the history of occupations, according to standard procedures for the follow-up of at risk workers.
  • Persons who received an oral and written information on the protocol and signed the informed consent form

Exclusion criteria

  • Pregnant or breastfeeding women
  • Subject legally protected (under judicial protection, guardianship), persons deprived of liberty

Trial design

Primary purpose

Other

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

23 participants in 2 patient groups

Patients exposed to silica
Experimental group
Treatment:
Biological: Blood collection
Biological: Blood sample
Patients exposed to asbestos fibres
Active Comparator group
Treatment:
Biological: Blood collection
Biological: Blood sample

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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