Effects of Sleep Deprivation on Diaphragm Command During an Inspiratory Endurance Trial in Healthy Volunteers. (NoSleepDiaph)

Poitiers University Hospital

Status

Completed

Conditions

Diaphragm

Healthy Volunteers

Sleep Deprivation

Treatments

Behavioral: Sleepless night

Behavioral: Normal sleep night

Study type

Interventional

Funder types

Other

Identifiers

NCT02725190

NoSleepDiaph

Details and patient eligibility

About

The purpose of this study is to assess the impact of sleep deprivation on subjective inspiratory endurance in healthy subjects.

Full description

Sleep in intensive care unit is altered and few studies have suggested that sleep deprivation (SD) could impact respiratory muscle endurance. A lack of inspiratory endurance could lengthen weaning from invasive ventilation. The purpose of this study is to confirm whether SD alters inspiratory endurance and to identify brain mechanisms involved in SD-induced decreased endurance. A group of 20 male healthy subjects will perform an inspiratory load trial after a normal sleep night and after a sleepless night. Electrophysiological parameters (EEG, motor evoked potentials) of the inspiratory motor command and sensory perceptions will be assessed before, during and after each trial.

Enrollment

20 patients

Sex

Male

Ages

25 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Male adult volunteers
Aged 25 to 45 years
Regularly sleeping more than 6 hours per night
Not excessive coffee consumers (< 3 expressos / day)
Non smokers
Absence of respiratory, cardiac, muscular or neurological disease or diabetes
With a neutral Horne & Ostberg score

Exclusion criteria

Previous history of respiratory disease or otorhinolaryngological (asthma, respiratory allergies, swallowing disorders, oropharyngeal malformations)
History of epilepsy or syncope during sleep deprivation
Taking medications that interfere with sleep (antidepressants, benzodiazepines...)