Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study

Poitiers University Hospital

Status

Completed

Conditions

Healthy Volunteers

Skeletal Muscle

Sleep Deprivation

Treatments

Behavioral: Sleepless night

Behavioral: Normal sleep night

Study type

Interventional

Funder types

Other

Identifiers

NCT03404427

HANDY-SLEEP

Details and patient eligibility

About

The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex. However, the inspiratory endurance test is associated with a feeling of dyspnea that could lead to premature arrest, and the inspiratory drive is complex, both automatic and voluntary. The investigator can reproduce this results on a simpler drive.

During the execution of an exercise involving repeated contractions of the hand it is possible to record the activation of the pre-motor cortex corresponding to the phase of preparation of the movement. The amplitude of these premotor potentials is proportional to the developed motive force.

The purpose of this study is to assess the impact of sleep deprivation on the muscular endurance of non-dominant in healthy subjects.

Hypothesis: Sleep deprivation causes a decrease in manual motor endurance by decreasing cortical pre-motor control.

Main objective: To compare the motor endurance of healthy subjects after a night's sleep and after a sleepless night.

Secondary objective: To compare the amplitude of premature cortical control at the beginning of the endurance test after a night's sleep and after a sleepless night.

Enrollment

21 patients

Sex

Male

Ages

25 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

adult male volunteers;
25 to 45 years old
regularly sleeping more than 6 hours per night;
no excessive consumers of coffee (<3 espressos / day);
absence of muscular or neurological pathology ;
with a BMI> 18 and <25 kg / m²;
Horne and Ostberg score> 31 and <69 ;

Exclusion criteria

female sex
history of neuromuscular disease ;
implanted metallic or electronic equipment (vascular stent, ocular implant, pacemaker ...)
history of epilepsy, or discomfort after sleep deprivation ;
poor sleepers (PSQI> 5);
exercising an activity in staggered hours;
regularly performing more than 2 nights without sleep per month;
taking drugs interfering with sleep (antidepressants, benzodiazepines ...);
having crossed 4 time zones in the previous 4 weeks.
current participation in another clinical research study;