Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis

Ege University

Status: Completed

Conditions: Generalized Aggressive Periodontitis; Smoking

Treatments: Procedure: Non-surgical periodontal therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT03512938

2014-DIS-013

Details and patient eligibility

About

Smoking is the major preventable risk factor in the initiation and progression of periodontal diseases. Periodontitis risk was found to be 3.9 times higher among smokers aged between 19-30 years and 2.8 times higher among smokers aged 31-40 years compared to non-smokers. Aggressive periodontitis (AgP), is characterized by a rapid attachment loss usually incompatible with the amount of plaque and dental calculus. It is often not possible to predict the prognosis of treatment with various treatment options in cases of aggressive periodontitis. It was hypothesized that non-smoker patients with generalized aggressive periodontitis (GAgP) will respond better to conventional mechanical non-surgical periodontal therapy compared to the smokers. Therefore, the aim of this study was to evaluate the effects of smoking on the outcomes of non-surgical periodontal treatment in terms of the clinical, biochemical and microbiological parameters.

Enrollment: 27 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Having at least six permanent teeth, including incisors and/or first molars with severe periodontal disease
• Having at least one site with probing depth (PD) and clinical attachment level (CAL) ≥5 mm and six teeth other than first molars and incisors with similar PD and CAL measurements
• Familial aggregation

Exclusion criteria

• Medical disorders such as diabetes mellitus, immunological disorders
• Having an antibiotic or periodontal treatment in the last 6 months
• Having <15 teeth

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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27 participants in 2 patient groups

Non-smoker Group

Active Comparator group

Description:

This group included non-smoker generalized aggressive periodontitis patients.

Treatment:

Procedure: Non-surgical periodontal therapy

Smoker Group

Experimental group

Description:

This group included smoker generalized aggressive periodontitis patients.

Treatment:

Procedure: Non-surgical periodontal therapy