Effects of Snuff and/or Red Wine om Metabolic Rate

University Hospital, Linkoeping

Status: Unknown

Conditions: Metabolic Rate; Hunger; Insulin Sensitivity

Treatments: Other: Wine with or without alcohol and snuff with or without nicotine

Study type: Interventional

Funder types: Other

Identifiers

NCT04547426

EPN2020-00839

Details and patient eligibility

About

About 14 healthy participants, consume a standardized breakfast combined with either using regular or nicotine-free moist snuff. The metabolic rate is measured every hour for four hours on each occasion starting in the morning. Participants are also randomized to get red wine or non-alcoholic red wine to the meal.

Full description

About 14 healthy participants, consume a standardized breakfast combined with either using regular or nicotine-free moist snuff. The metabolic rate is measured measured before the meal and then every hour for a total of four hours on each occasion that starts in the morning. Participants are also randomized to get red wine or non-alcoholic red wine to the meal. Since there are four possible combinations of the wine and the snuff, all participants do the test on four occasions. Except for metabolic rate we will also analyze hormone responses regarding appetite or hunger.

Enrollment: 14 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: No significant disease -

Exclusion Criteria: known illnesses, thyroid disease, need to take prednisolone, psychiatric disease,inability to understand Swedish

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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14 participants in 4 patient groups, including a placebo group

red wine and snuff

Active Comparator group

Description:

regular red wine and moist snuff

Treatment:

Other: Wine with or without alcohol and snuff with or without nicotine

red wine and nicotine-free snuff

Active Comparator group

Description:

regular red wine and nicotine-free snuff

Treatment:

Other: Wine with or without alcohol and snuff with or without nicotine

non alcoholic red wine and regular moist snuff

Active Comparator group

Description:

non alcoholic red wine and regular moist snuff with nicotine

Treatment:

Other: Wine with or without alcohol and snuff with or without nicotine

non-alcoholic red wine and nicotine-free snuff

Placebo Comparator group

Description:

Non-alcoholic red wine and nicotine-free snuff

Treatment:

Other: Wine with or without alcohol and snuff with or without nicotine