Effects of Soy Protein on Serum paraoxonase1 Activity and Lipoproteins in Postmenopausal Women

Iran University of Medical Sciences

Status

Completed

Conditions

Hyperlipidemia

Postmenopausal

Treatments

Procedure: soy consumption

Study type

Interventional

Funder types

Other

Identifiers

NCT00457262

1344

Details and patient eligibility

About

paraoxonase 1 is involved to prevent LDL and HDL oxidation,so increase of it's activity leads to lower risk of coronary heart disease.In postmenopausal women ,we have decrease of paraoxonase1 activity and soy proteins may increase paraoxonase1 activity

Full description

In a double blind clinical randomised clinical trial with parallel design this study was done.52 postmenopausal women were randomly assigned to 50 g/d soy protein or placebo for 10 weeks.serum lipoproteins and pon1 activity were measured at baseline and 10th week.There were significant increase in PON! activity and significant decrease in LDL-C,LDL-C/HDL-C,TC/HDL-C and TG/HDL-C in soy group compare to placebo group.

Sex

Female

Ages

51 to 57 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Cessation of menes for more than 1 year, elevation for more than 1 year
Elevation of FSH level
Total cholesterol
Triglyceride more than 200 mg/dl

Exclusion criteria

Chronic disease (heart disease, cancer, diabetes, hepatic, kidney and thyroid disease)
Antihypertensive drugs
Antibiotics
Lipid lowering drugs
Sex hormone treatment
Hysterectomy
Diet rich in soy protein