Effects of Spinal vs General Anesthesia on Systemic Inflammation in PCNL (PCNL-ANES-INF)

Elazıg Fethi Sekin Sehir Hastanesi

Status: Enrolling

Conditions: Systemic Inflammation; Percutaneous Nephrolithotomy; Anesthesia Techniques

Study type: Observational

Funder types: Other

Identifiers

NCT07326670

PCNL-ANES-INFLAM-2025

Details and patient eligibility

About

This observational study aims to compare the effects of spinal and general anesthesia on perioperative systemic inflammatory response in patients undergoing percutaneous nephrolithotomy (PCNL). Systemic inflammatory indices derived from routine complete blood count parameters, including Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), Neutrophil-to-Lymphocyte Ratio (NLR), and Red Cell Distribution Width (RDW), will be evaluated. Preoperative and postoperative laboratory values will be analyzed to determine whether the type of anesthesia influences systemic inflammatory markers and related clinical outcomes.

Enrollment: 90 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status class I-III
• Patients aged 18 years and older

Exclusion criteria

• American Society of Anesthesiologists (ASA) physical status class IV or V
• Patients younger than 18 years
• Active infection or diagnosis of sepsis
• Malignancy
• Chronic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus)
• Use of immunosuppressive therapy
• Pregnancy

Trial design

90 participants in 2 patient groups

Spinal Anesthesia Group

Description:

Patients undergoing percutaneous nephrolithotomy under spinal anesthesia as part of routine clinical practice. No additional intervention is performed for the purposes of the study.

General Anesthesia Group

Description:

Patients undergoing percutaneous nephrolithotomy under general anesthesia as part of routine clinical practice. No additional intervention is performed for the purposes of the study.