Effects of Standing and Light-intensity Activity on Ambulatory Blood Pressure and Blood Glucose

Arizona State University (ASU)

Status and phase: Completed; Phase 3

Conditions: Hypertension; Diabetes; Sleep

Treatments: Other: Changing posture; Other: Maintaining posture and energy expenditure; Other: Increasing energy expenditure and changing posture; Other: Increasing energy expenditure

Study type: Interventional

Funder types: Other

Identifiers

NCT02616809

1306009298

Details and patient eligibility

About

This study aims to test the short-term effects of intermittent standing, slow cycling and slow walking, compared to sitting, on continuous blood glucose and ambulatory blood pressure among pre-hypertensive and pre-diabetic adults.

Full description

This study will enroll 10 adults who will each complete four experimental conditions in random order. Each of the four experimental conditions are as follows: 1) sit continuously for 8 hours in a simulated office environment, 2) break-up sitting time with standing based on set hourly intervals, 3) break-up sitting time with slow-walking on a treadmill desk based on set hourly intervals, 4) increase energy expenditure by slow cycling based on set hourly intervals. Participants will completed each condition one week apart and dietary intake will be standardized by giving participants the same meals during each intervention condition. Study measures will include: anthropometrics (height and weight), blood pressure, fasting glucose, 24-continuous glucose monitoring, full-day ambulatory blood pressure monitoring, cognitive testing (cognitive performance), energy expenditure, physical activity via accelerometer, sleep via accelerometer, and heart rate.

Enrollment: 10 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• pre-hypertensive (systolic blood pressure 120-139 mmHg, or diastolic blood pressure 80-89 mmHg)
• impaired fasting glucose (5.6-6.9 mmil/L)
• not meeting the physical activity guidelines for adults (>=150 min/wk of moderate-to-vigorous physical activity)

Exclusion criteria

• smoking, pregnancy, known coronary heart disease, orthopedic limitations for performing physical activity, taking medications to control high blood pressure or high blood glucose, special dietary requirements, and being advised by a doctor to avoid prolonged periods of sitting.

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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10 participants in 4 patient groups

Sitting

Experimental group

Description:

Participants will sit continuously for 8 hours in a simulated office environment

Treatment:

Other: Maintaining posture and energy expenditure

slow cycling

Experimental group

Description:

Participants will cycle at regular hourly intervals during an 8-hr simulated office environment

Treatment:

Other: Increasing energy expenditure

standing

Experimental group

Description:

Participants will change posture (from sitting to standing) during hourly intervals for an 8-hr period in a simulated office environment

Treatment:

Other: Changing posture

slow walking

Experimental group

Description:

Participants will transition from sitting to slow walking on a treadmill desk at regular hourly intervals during an 8-hr period in a simulated office environment

Treatment:

Other: Increasing energy expenditure and changing posture