Effects of Standing on Glycemia in Prediabetic Adults

University of Minnesota (UMN)

Status: Completed

Conditions: Prediabetes

Treatments: Other: Sitting OGTT; Other: Sitting CGM; Other: Standing CGM; Other: Standing OGTT

Study type: Interventional

Funder types: Other

Identifiers

NCT01884792

1208M18741

Details and patient eligibility

About

The study is a crossover, pilot trial examining the acute effects of standing on blood sugar in prediabetic, working adults. Participants will complete oral glucose tolerance testing, once while sitting and once while standing. They will also wear a continuous blood sugar monitor once while sitting at their desk for a week and once while using their desk as a sit-stand desk with a goal of standing intermittently for at least half of the work day. Physical activity levels will be measured with an accelerometer. The primary study hypothesis is that blood sugar will differ between the sitting and standing conditions for each of the tests performed.

Enrollment: 20 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Fasting blood glucose >100 mg/dl
• Employed full-time working at least 35 hours/week
• Able to safely begin a light physical activity program

Exclusion criteria

• Heart disease
• Renal disease
• Peripheral neuropathy
• Retinopathy
• PAD
• Lower limb amputation
• pregnancy
• active substance abuse
• current smoker
• psychiatric disorder
• severe visual impairment
• immune-compromised individuals,
• enrollment in a physical activity study
• use of insulin or an insulin pump

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 4 patient groups, including a placebo group

Sitting Oral Glucose Tolerance Test

Placebo Comparator group

Description:

An OGTT is performed while the subject sits at their desk for the entire 2-hour period. 5 blood sugar measurements are taken and a 75g dextrose beverage is consumed following the first, baseline blood sugar reading. The blood sugar is then measured every 30 minutes up to 120 min.

Treatment:

Other: Standing OGTT

Other: Sitting OGTT

Standing Oral Glucose Tolerance Test

Experimental group

Description:

The participant stands at their desk for the duration of the 2-hour blood sugar test. The same procedure is performed as in the sitting condition.

Treatment:

Other: Standing OGTT

Other: Sitting OGTT

Sitting Continuous Glucose Monitor

Placebo Comparator group

Description:

A continuous blood glucose monitor is worn for 5 days while at work. In the sitting condition the participant only sits at their desk for the duration of the week. Blood sugar is monitored 4 times per day to calibrate the CGM and an accelerometer is worn to track physical activity.

Treatment:

Other: Sitting CGM

Other: Standing CGM

Standing Continuous Glucose Monitor

Experimental group

Description:

Participants are instructed to stand intermittently for at least half of their work day during this 5 day period. Blood sugar is monitored and physical activity is tracked with an accelerometer.

Treatment:

Other: Sitting CGM

Other: Standing CGM