Effects of Statins on Pro- and Antioxidant Status : Link With Statin-Associated Myopathy.

University Hospital Center (CHU)

Status: Completed

Conditions: Healthy

Treatments: Drug: Simvastatin

Study type: Interventional

Funder types: Other

Identifiers

NCT00285181

UF7808

Details and patient eligibility

About

To evaluate the effects of a 8-week treatment with 80 mg/day simvastatin on prooxidant and antioxidant status at rest and after exercise, on mitochondrial respiration and calcium release in skeletal muscle, and on aérobic aptitude in 24 healthy male subjects.

Full description

Day 1 : baseline oxidative status, lipid profile, exercice test, start of randomized treatment Day 53 : muscular biopsy Day 57 : follow-up oxidative status, lipid profile, exercice test, end of treatment

Enrollment: 24 estimated patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI between 18.0 and 25.00

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind