Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3

The University of Chicago

Status and phase: Completed; Phase 2

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Treatments: Other: 100% oxygen; Drug: 0.4% isoflurane; Drug: 0.2% isoflurane; Drug: 30% N2O

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000251

R01DA008391 (U.S. NIH Grant/Contract)

NIDA-08391-3

R01-08391-3

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.

Enrollment: 10 patients

Sex: All

Ages: 21 to 32 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 6 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Subjects inhale 100% oxygen

Treatment:

Other: 100% oxygen

30% N2O

Active Comparator group

Description:

Subjects inhale 30% N2O

Treatment:

Drug: 30% N2O

0.2% isoflurane

Active Comparator group

Description:

Subjects inhale 0.2% isoflurane

Treatment:

Drug: 0.2% isoflurane

0.4% isoflurane

Active Comparator group

Description:

Subjects inhale 0.4% isoflurane

Treatment:

Drug: 0.4% isoflurane

0.2% isoflurane + 30% N2O

Active Comparator group

Description:

Subjects will inhale a combination of 0.2% isoflurane and 30% N2O

Treatment:

Drug: 0.2% isoflurane

Drug: 30% N2O

0.4% isoflurane + 30% N2O

Active Comparator group

Description:

Subjects will inhale a combination of 0.4% isoflurane and 30% N2O

Treatment:

Drug: 0.4% isoflurane

Drug: 30% N2O