Effects of Subanesthetic Concentrations of Nitrous Oxide - 1

The University of Chicago

Status and phase: Completed; Phase 2

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Treatments: Drug: 40% N2O; Drug: 20% N2O; Drug: 30% N2O

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000249

R01DA008391 (U.S. NIH Grant/Contract)

NIDA-08391-1

R01-08391-1

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.

Enrollment: 10 patients

Sex: All

Ages: 21 to 37 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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10 participants in 4 patient groups

Control

No Intervention group

Description:

Subject inhaled 0% N2O for 40 minutes with cold immersion at 10 and 30 minutes

20% N2O

Active Comparator group

Description:

Subject inhaled 20% N2O for 40 minutes with cold immersion at 10 & 30 minutes

Treatment:

Drug: 20% N2O

30% N2O

Active Comparator group

Description:

Subject inhaled 30% N2O for 40 minutes with cold immersion at 10 and 30 minutes

Treatment:

Drug: 30% N2O

40% N2O

Active Comparator group

Description:

Subject inhaled 40% N2O for 40 minutes with cold immersion at 10 and 30 minutes

Treatment:

Drug: 40% N2O