Effects of Subanesthetic Concentrations of Nitrous Oxide - 1

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The University of Chicago

Status and phase

Completed
Phase 2

Conditions

Opioid-Related Disorders
Substance-Related Disorders

Treatments

Drug: 40% N2O
Drug: 20% N2O
Drug: 30% N2O

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT00000249
R01DA008391 (U.S. NIH Grant/Contract)
NIDA-08391-1
R01-08391-1

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To examine effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans.

Enrollment

10 patients

Sex

All

Ages

21 to 37 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

10 participants in 4 patient groups

Control
No Intervention group
Description:
Subject inhaled 0% N2O for 40 minutes with cold immersion at 10 and 30 minutes
20% N2O
Active Comparator group
Description:
Subject inhaled 20% N2O for 40 minutes with cold immersion at 10 & 30 minutes
Treatment:
Drug: 20% N2O
30% N2O
Active Comparator group
Description:
Subject inhaled 30% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Treatment:
Drug: 30% N2O
40% N2O
Active Comparator group
Description:
Subject inhaled 40% N2O for 40 minutes with cold immersion at 10 and 30 minutes
Treatment:
Drug: 40% N2O

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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