Effects of Supplementation With Linseed Oil on Blood Lipids in Vegetarians

University of Jena

Status

Completed

Conditions

Inter-conversion n-3 PUFA, Vegetarians

Treatments

Dietary Supplement: Linseed oil

Study type

Interventional

Funder types

Other

Identifiers

NCT01788917

H39_09

Details and patient eligibility

About

The study was performed to investigate the effects of a daily consumption of linseed oil on fatty acid distribution in plasma and red blood cell lipids and blood lipids in vegetarians.

Full description

Recent studies suggest that the daily intake of n-3 LC-PUFA (EPA and DHA) can modulate cardiovascular risk factors and prevent lifestyle diseases.

The major dietary source of EPA and DHA is seafood (seaweeds and fatty cold water fishes), but they can also be found in lean red meat, in organ meats such as liver and brain. Vegetarians who do not eat meat or fish, have very low or negligible intakes of EPA (< 5 mg EPA/d) and DHA.

The purpose of the present study is to explore the tissue distribution and inter-conversion of ALA to n-3 LC-PUFA as consequence of linseed oil supplementation in vegetarians.

Eight vegetarians (3 m; 5 f) who do not eat meat, fish or seaweeds such as algae foods since least two years ago and two subjects (1 m; 1w) who consume the normal western style diet living in Jena (Germany) entered the study. The participants consumed 10 mL linseed oil per day for 10 weeks. The resulting daily dose of ALA was approx. 5.7 g/d.

Enrollment

10 patients

Sex

All

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

for the vegetarian sub-group : vegetarian diet pattern

Exclusion criteria

high performance sport, daily alcohol intake and the in-take of dietary supplements (e.g., fish oil capsules)
for the vegetarian sub-group, the consumption of fish and algae products (e.g. seaweeds, sushi)