Effects of Systemic Drugs on Intraocular Pressure

Benha University

Status: Enrolling

Conditions: Hypertension; Glaucoma Secondary to Drugs, Bilateral; Glaucoma Suspect; Glaucoma, Angle-Closure

Treatments: Drug: Antihistaminics; Drug: Antihypertensive Agents

Study type: Observational

Funder types: Other

Identifiers

NCT05328921

Rc 9-22

Details and patient eligibility

About

To assess intraocular pressure changes among glaucoma patients on systemic antihypertensive and antihistaminic drugs.

Full description

Changes in intraocular pressure in glaucomatous patients with narrow angle may elicit attacks of angle closure glaucoma.

In this study we aim to assess changes in intraocular pressure (IOP) among glaucomatous patients on systemic antihypertensive and antihistaminic drugs.

Enrollment: 200 estimated patients

Sex: All

Ages: 35 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with narrow angle glaucoma on systemic antihypertensive and/or antihistaminic drugs.

Exclusion criteria

• open angle glaucoma patients confirmed by gonioscopy examination.
• Cases with dense corneal opacity or iris trauma that may affects gonioscopy examination.
• cases with secondary glaucoma.

Trial design

200 participants in 3 patient groups

Antihypertensive drugs group

Description:

Changes in IOP among patients on antihypertensive drugs

Treatment:

Drug: Antihypertensive Agents

Antihistaminic drugs group

Description:

Changes in IOP among patients on antihistaminic drugs

Treatment:

Drug: Antihistaminics

Antihypertensive and antihistaminic drugs group

Description:

Changes in IOP among patients on both antihypertensive and antihistaminic drugs

Treatment:

Drug: Antihypertensive Agents

Drug: Antihistaminics