Effects of Tai Chi Chuan With Different Doses on Cognitive Function in Elderly Patients With Mild Cognitive Impairment

Lidian Chen

Status: Not yet enrolling

Conditions: Mild Cognitive Impairment

Treatments: Behavioral: Tai Chi Chuan （dose 6）; Behavioral: Tai Chi Chuan （dose 7）; Behavioral: Tai Chi Chuan （dose 1）; Behavioral: Tai Chi Chuan （dose 2）; Behavioral: Tai Chi Chuan （dose 5）; Behavioral: Tai Chi Chuan （dose 8）; Behavioral: Tai Chi Chuan （dose 9）; Behavioral: Tai Chi Chuan （dose 4）; Behavioral: Tai Chi Chuan （dose 3）

Study type: Interventional

Funder types: Other

Identifiers

NCT06372535

FujianUTCM-1

Details and patient eligibility

About

To determine the impact of Tai Chi Chuan with different exercise volume on cognitive function in elderly patients with mild cognitive impairment.

Full description

Taking MCI as a potential gateway, early intervention to delay the occurrence of dementia has become an important consensus in this field. Exercise is an important means to improve cognitive function in MCI, but the effect of exercise is influenced by the dosage. Tai Chi Chuan, is a moderate intensity aerobic exercise. Previous studies by our team and others had confirmed its effect on cognitive function in MCI. However, the dose parameters of Tai Chi Chuan exercise varied in these studies, and the dose-response relationship is still unclear. The purpose of this study is to explore the dose-response relationship between different volume of Tai Chi Chuan exercise and cognitive function（global cognition and cognition of subdomains）in elderly MCI patients.

Enrollment: 540 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Presence of mild cognitive impairment, not demented;
2. Age ≥ 60 years old;
3. Informed consent and voluntary participation.

Exclusion criteria

1. Geriatric Depression Scale score ≥ 9 points
2. Cognitive impairment caused by other reasons, taking drugs, poisoning, etc;
3. Suffer from severe musculoskeletal system diseases and other contraindications to exercise and are not suitable for Tai Chi training, such as those who suffer from stroke, Parkinson's disease, and have a history of lower limb arthritis, hip and knee joint replacement, etc;
4. Patients with severe heart, liver, kidney failure, malignant tumors, and other major diseases;
5. Individuals with visual/auditory impairments, writing/reading impairments, illiteracy, etc. that affect training and evaluation;
6. Individuals with uncontrolled hypertension (systolic blood pressure greater than 160mmHg or diastolic blood pressure greater than 100mmHg after medication);
7. Participating in other experiments that influence this study;
8. Engaged in regular exercise in the last three months (at least 3 times a week, at least 20 minutes of regular exercise each time.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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540 participants in 9 patient groups

Tai Chi Chuan Group1

Experimental group

Description:

Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 8 weeks.

Treatment:

Behavioral: Tai Chi Chuan （dose 1）

Tai Chi Chuan Group2

Experimental group

Description:

Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 16 weeks.

Treatment:

Behavioral: Tai Chi Chuan （dose 2）

Tai Chi Chuan Group3

Experimental group

Description:

Tai Chi Chuan 0.5 hour/session, 5 sessions/week for 24 weeks.

Treatment:

Behavioral: Tai Chi Chuan （dose 3）

Tai Chi Chuan Group4

Experimental group

Description:

Tai Chi Chuan 1 hour/session, 5 sessions/week for 8 weeks.

Treatment:

Behavioral: Tai Chi Chuan （dose 4）

Tai Chi Chuan Group5

Experimental group

Description:

Tai Chi Chuan 1 hour/session, 5 sessions/week for 16 weeks.

Treatment:

Behavioral: Tai Chi Chuan （dose 5）

Tai Chi Chuan Group6

Experimental group

Description:

Tai Chi Chuan 1 hour/session, 5 sessions/week for 24 weeks.

Treatment:

Behavioral: Tai Chi Chuan （dose 6）

Tai Chi Chuan Group7

Experimental group

Description:

Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 8 weeks.

Treatment:

Behavioral: Tai Chi Chuan （dose 7）

Tai Chi Chuan Group8

Experimental group

Description:

Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 16 weeks.

Treatment:

Behavioral: Tai Chi Chuan （dose 8）

Tai Chi Chuan Group9

Experimental group

Description:

Tai Chi Chuan 1.5 hour/session, 5 sessions/week for 24 weeks.

Treatment:

Behavioral: Tai Chi Chuan （dose 9）