Effects of tDCS in M1 and DLPFC on Pain Processing in Healthy Volunteers

Universidad Rey Juan Carlos

Status: Completed

Conditions: Pain Processing in Healthy Volunteers

Treatments: Device: Transcranial direct current stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT04432363

30012020204820

Details and patient eligibility

About

The purpose of this study is to evaluate the effects of a direct current applied transcranial over two cortical areas on healthy volunteers' pain processing.

Enrollment: 30 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 18 and 40 years
• Comprehension of the study tasks

Exclusion criteria

• Presence of pain in the previous 6 months
• Altered sensitivity in the tested regions
• Intolerance to electrotherapy
• Presence of pacemakers or any other implanted device
• Ulcers or scars in the skin at the location of the electrodes
• Treatment with direct current stimulation within one week
• Pregnancy
• Frequent headaches
• Epilepsy
• History of neuromuscular disease
• Previous clinical history of cervical surgery
• Injuries or surgery affecting the upper limb
• diabetes mellitus
• Cardiovascular diseases
• Oncological diseases
• Consumption of analgesic drugs 7 days before the study

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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30 participants in 3 patient groups

M1 stimulation

Active Comparator group

Description:

A 20 minutes 1mA direct current stimulation over left M1.

Treatment:

Device: Transcranial direct current stimulation

M1+DLPFC stimulation

Active Comparator group

Description:

A 20 minutes 1mA direct current stimulation over left M1 and 1mA direct current stimulation over left DLPFC.

Treatment:

Device: Transcranial direct current stimulation

Sham stimulation

Sham Comparator group

Description:

A 20 minutes sham stimulation where the device only is working first 30s and last 30s of the intervention and have a 10 seconds fade out in intensity at each ramp.

Treatment:

Device: Transcranial direct current stimulation