Effects of TEAS on Stress Response During Extubation of General Anesthesia in Elderly Patients

China Medical University

Status: Completed

Conditions: Stress

Treatments: Device: Hwato Electronic Acupuncture Treatment Instrument; Device: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02533388

TEAS on stress

Details and patient eligibility

About

Elderly patients have an increased risk of stress responses during extubation after general anaesthesia for an elective supratentorial craniotomy. How to decrease the stress responses during extubation after general anaesthesia remains challenging for the anaesthesiologist. In this study, we aimed to investigate whether transcutaneous electrical acupoint stimulation (TEAS) might decrease the stress responses and improve the quality of recovery in the elderly patients who underwent elective supratentorial craniotomy under general anaesthesia.

Full description

A total of 100 elderly patients scheduled for elective supratentorial craniotomy under propofol-remifentanil total intravenous anaesthesia were randomly divided to either TEAS group (received stimulation at LI4, PC6, LU7, LU5, LI18 and ST9 acupoints, 2/10Hz, 6-15 mA) or Sham group (received no stimulation). The primary outcomes were the haemodynamic parameters and plasma concentrations of epinephrine (E), norepinephrine (NE) and cortisol (Cor). The secondary outcomes were the consumption of remifentanil and propofol, the time from discontinuation of anesthetics to extubation and reorientation, extubation quality score, the quality of postoperative recovery and postoperative complications.

Enrollment: 100 patients

Sex: All

Ages: 60 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA Ⅱ～Ⅲ
• aged 60-70years
• scheduled for elective supratentorial craniotomy under general anaesthesia

Exclusion criteria

• past or current history of cardiovascular and/or cerebrovascular diseases
• diabetes
• pre-existing liver, lung or kidney dysfunction
• psychiatric disorders
• potentially difficult airway
• previous acupuncture treatment
• infection at the stimulus sites

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Quadruple Blind

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100 participants in 2 patient groups

Electrical acupoint stimulation

Experimental group

Description:

Electrical acupoint stimulation at the Hegu (LI4), Neiguan (PC6), Lieque (LU7), Chize (LU5), Futu (LI18) and Renying (ST9) acupoints, Stimulus frequency was an alternate dense-disperse frequency of 2/10 Hz ( 2 Hz for 10 s and 10 Hz for 5 s). The optimal intensity ranged from 6-15 mA, which was adjusted to maintain a slight twitching of the regional muscles according to individual maximum tolerance.

Treatment:

Device: Hwato Electronic Acupuncture Treatment Instrument

Sham stimulation

Sham Comparator group

Description:

Sham stimulation only connected to the apparatus, but electronic stimulation was not applied.

Treatment:

Device: Placebo