Effects of the Cornelian Cherry Supplementation on the Selected Physiological Parameters in Marathon Runners

Wroclaw Medical University

Status

Completed

Conditions

Healthy

Treatments

Dietary Supplement: Cornus mas lyophilisate

Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT07194720

DEREN.23.25

Details and patient eligibility

About

Growing body of evidence indicates favorable effects of Cornus mas (Cornelian cherry) supplements on cardiometabolic risk, including the improvement of HDL and glycemic indices, in line with vascular benefits. Experimental data feature bioactives from Cornelian cherry as potential modulators of vascular function and blood pressure, plausibly via endothelial nitric oxide-related pathways, with possible downstream effects on autonomic reflex control; nevertheless, such links in humans remain poorly explored to date, especially in terms of endurance training and hypoxia tolerance.

In this cross-over, placebo-controlled study, a group of healthy amateur long-distance runners underwent two stages of a four-week dietary intervention (separated by four weeks of washout period), receiving Cornelian cherry lyophilisate or placebo. Each supplementation stage was accompanied by the comprehensive evaluation of the cardio-respiratory parameters and endothelial function.

Enrollment

18 patients

Sex

Male

Ages

45 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

age above 45 years

Exclusion criteria

chronic disease of the nervous, cardiovascular or respiratory system
disease of the digestive system, including history of the intestinal surgery, inflammatory bowel disease, celiac disease, lactose intolerance and other malabsorption disorders
blood pressure-lowering treatment within the past year
tobacco smoking within the past year
antibiotic/probiotic treatment and laxative/prokinetic usage in three months preceding the anticipated enrollment