Effects of the Dietary Inflammatory Index on Systemic Inflammation Markers and Gastrointestinal Symptoms in Individuals With Bariatric Surgery

Istanbul Bilgi University

Status: Invitation-only

Conditions: Systemic Inflammation; Systemic Inflammation Markers; Bariatric Sleeve Gastrectomy; Bariatric Surgery; Inflamation; Dietary Inflammatory Index (DII)

Treatments: Other: Observational Intervention; Other: Observetional

Study type: Observational

Funder types: Other

Identifiers

NCT07293624

BARINFLAMMATION

Details and patient eligibility

About

The goal of this observational cross-sectional study is to evaluate the relationships between the Dietary Inflammatory Index (DII), systemic inflammatory markers, and gastrointestinal symptoms in adults aged 18-65 who have undergone bariatric surgery.

The main questions it aims to answer are:

Does the inflammatory potential of the diet affect systemic inflammation levels (such as SII, CRP, and WBC) in the post-operative period?

Is there an association between the DII score and gastrointestinal symptoms (e.g., bloating, gas, abdominal pain)?

Participants who are at least three months post-bariatric surgery will provide dietary intake data to calculate DII scores, undergo blood tests to measure inflammatory markers, and complete assessments regarding their gastrointestinal symptoms.

Enrollment: 70 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult individuals between the ages of 18 and 65,
• Having undergone bariatric surgery at least 3 months prior,
• Individuals who agreed to participate voluntarily in the study and signed the informed consent form,
• Having the cognitive ability/literacy to completely complete the food consumption record and questionnaire forms,
• Individuals with no health conditions that would prevent blood tests,
• Individuals who were regularly followed up after surgery and had no postoperative complications.

Exclusion criteria

• Individuals diagnosed with gastrointestinal diseases such as inflammatory bowel disease, celiac disease, or short bowel syndrome before or after bariatric surgery,
• Those with a history of diseases that could affect systemic inflammation, such as autoimmune disease, active infection, or cancer,
• Individuals regularly taking medications that could affect inflammation levels, such as corticosteroids, immunosuppressants, or anti-inflammatory drugs,
• Individuals actively or recently using probiotic supplements,
• Pregnant or breastfeeding women,
• Those with a history of chronic alcohol use or substance abuse,
• Individuals who experienced serious postoperative complications after surgery (e.g., anastomotic leak, serious infection, or conditions requiring reoperation),
• Individuals with cognitive or communication disabilities that prevented them from providing the necessary information and data to the study or who were lost to follow-up,
• Individuals with chronic organ failure,
• Individuals with a psychiatric diagnosis,
• Individuals who did not consent to their data being used for scientific purposes.