Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the Enteric Nervous System During the Syndrome of the Irritable Bowel

Centre Hospitalier Universitaire de Nice

Status: Unknown

Conditions: Irritable Bowel Syndrome

Treatments: Procedure: Colic biopsies

Study type: Interventional

Funder types: Other

Identifiers

NCT00742118

05-API-08

Details and patient eligibility

About

Patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. The investigators aimed to investigate:

1. paracellular permeability in colonic biopsies of IBS patient
2. the ability of soluble factors from colonic biopsies to reproduce in vitro these alterations

Enrollment: 200 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients needing coloscopy

Exclusion criteria

• Disrupted coagulation results
• Cancer even healed
• Known food allergy.
• Alcohol consumption >30g/day

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

200 participants in 3 patient groups

2

Experimental group

Description:

patient with chronic inflammatory intestinal disease

Treatment:

Procedure: Colic biopsies

3

Other group

Description:

patient having no symptoms

Treatment:

Procedure: Colic biopsies

1

Experimental group

Description:

patient with irritable bowel syndrome

Treatment:

Procedure: Colic biopsies