EFFects of Thrombophilia on the Outcomes of Assisted Reproduction Technologies

G. d'Annunzio University

Status: Completed

Conditions: Thrombophilia; Reproductive Techniques; Embryo Implantation; Birth Rate

Study type: Observational

Funder types: Other

Identifiers

NCT02407730

EFFORT

Details and patient eligibility

About

Both hereditary and acquired thrombophilia have been associated with recurrent miscarriage and pregnancy complications. Thrombophilia could favor the development of thrombosis of the maternal vasculature and obstacle placentation. Some studies have suggested a role of thrombophilia in the failure of assisted reproductive techniques although this association has been recently questioned. The scope of this study is to evaluate the effect of thrombophilia on the implantation rate and live birth rate in women undergoing ART.

Design: prospective, observational study Primary end-point: live birth rate. Secondary end-points: implantation rate, venous thromboembolic events during ART up to 6 weeks post-partum

Enrollment: 687 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• women undergoing ART
• age 18 years or older

Exclusion criteria

• ongoing anticoagulant therapy
• previous venous thromboembolism
• no informed consent