Effects of Thyroid Hormone Withdrawal on Metabolic Parameters During Radioactive Iodine Therapy in Thyroid Cancer

Konkuk University Medical Center

Status: Unknown

Conditions: Hypothyroidism

Study type: Observational

Funder types: Other

Identifiers

NCT01744769

KUH1010379

Details and patient eligibility

About

1. The incidence of differentiated thyroid cancer is increasing in Korea. A significant number of them experience severe hypothyroidism in preparation for radioactive iodine (RAI) therapy after total thyroidectomy.
2. Because the function of thyroid hormone is closely linked with lipid and glucose metabolism, overt hypothyroidism after thyroid hormone withdrawal during RAI therapy may induce the changes of metabolic parameters.
3. We investigate the effects of thyroid hormone withdrawal on metabolic and cardiovascular parameters during radioactive iodine therapy in differentiated thyroid cancer.

Full description

1. Study design measurement of various parameters during hypothyroid state (before 1 month, the day and after 1 month of RAI therapy)

2. Measurements

   1. Measurement of metabolic and cardiovascular parameters

      • glucose profiles : HbA1c, fasting glucose level
      • lipid profiles : free fatty acid, total, LDL-, HDL-, cholesterol, triglyceride
      • adipocytokines : retinol binding protein(RBP)
      • 4, leptin, resistin, adiponectin
      • markers of endothelial and cardiac function : high-sensitivity C-reactive protein(hsCRP), homocystein, B-type natriuretic peptide(BNP)
      • bone turnover markers : CTX, bone ALP

   2. Scoring of symptoms and signs of hypothyroidism (Zulewski score)

      • symptoms
      • physical signs

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• radioiodine therapy after total thyroidectomy in differentiated thyroid cancer
• age over 18

Exclusion criteria

• kidney failure, liver failure, heart failure
• infection
• inflammation
• autoimmune disease
• other chronic disease

Trial design

80 participants in 1 patient group

Hypothyroidism for RAI

Description:

The group of patients who experience hypothyroidism after thyroid hormone withdrawal for radioactive iodine(RAI) therapy