Effects of Time-restricted Eating and Aerobic Exercise Training in Women With Overweight and Obesity

Federal University of Rio Grande do Sul

Status: Not yet enrolling

Conditions: Time Restricted Eating; Overweight and Obesity; Time Restricted Feeding; Obesity; Intermittent Fasting

Treatments: Behavioral: Dietary and Exercise Approaches; Behavioral: Dietary Approach

Study type: Interventional

Funder types: Other

Identifiers

NCT06302231

16690919.5.0000.5347

Details and patient eligibility

About

Time-restricted eating (TRE) is a dietary approach that aims to increase fasting time and decrease the eating window. Promising TRE effects on weight loss and improvements in some cardiometabolic risk factors have been reported in studies in animals and humans. However, the impacts of TRE combined with aerobic exercise training in individuals with overweight and obesity have been insufficiently investigated.

Additionally, aerobic training performed in a fasted state appears to promote physiological adaptations that may improve the metabolic health in individuals with overweight and obesity.

The present study investigates the effects of 8 weeks of TRE associated with aerobic training in a fasted state versus a fed state on body composition and cardiometabolic parameters in women with overweight and grade 1 obesity.

Enrollment: 30 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female;
• Body mass index (BMI) between 25 and 34.9 kg/m²;
• Age between 20 and 40 years;
• Not engaged in any structured exercise program;
• Weight stable for ~3 months before the beginning of the study;
• Able to give written informed consent.

Exclusion criteria

• Current smoker;
• Habitual drinkers (>1 serving/day) of alcoholic beverages;
• Cardiometabolic diseases (dyslipidemia, diabetes, hypertension, etc);
• Current treatment with medication or supplements which significantly affect the main studied variables;
• Bariatric surgery;
• Night-shift workers;
• Strict vegetarian/vegan;
• Pregnancy, planned pregnancy (within the study period), lactating;
• Postmenopausal women;
• Self-reported menstrual cycle irregularities;
• Habitual fasting window >16 hours;
• Concomitant participation in other studies.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 3 patient groups

Time-Restricted Eating and Aerobic Exercise Performed in Fasted State

Experimental group

Description:

Participants will be prescribed a diet plan to promote weight loss, but no food will be provided to them. Diets will be formulated to contain 50% energy as carbohydrate, 20% as protein, and 30 % as fat. Participants will be instructed to divide their daily energy intake between three meals each day (lunch, afternoon snack, and dinner). Participants will be instructed to eat from 12.00 until 20.00 (8-hour window). Aerobic exercise sessions will be carried out during the morning shift with participants in a fasted state.

Treatment:

Behavioral: Dietary and Exercise Approaches

Behavioral: Dietary and Exercise Approaches

Time-Restricted Eating and Aerobic Exercise Performed in Fed State

Active Comparator group

Description:

Participants will be prescribed a diet plan to promote weight loss, but no food will be provided to them. Diets will be formulated to contain 50% energy as carbohydrate, 20% as protein, and 30 % as fat. Participants will be instructed to divide their daily energy intake between three meals each day (lunch, afternoon snack, and dinner). Participants will be instructed to eat from 12.00 until 20.00 (8-hour window). Aerobic exercise sessions will be carried out during the afternoon shift with participants in a fed state.

Treatment:

Behavioral: Dietary and Exercise Approaches

Behavioral: Dietary and Exercise Approaches

Time-Restricted Eating

Other group

Description:

Participants will be prescribed a diet plan to promote weight loss, but no food will be provided to them. Diets will be formulated to contain 50% energy as carbohydrate, 20% as protein, and 30 % as fat. Participants will be instructed to divide their daily energy intake between three meals each day (lunch, afternoon snack, and dinner). Participants will be instructed to eat from 12.00 until 20.00 (8-hour window). Participants in this arm will not perform aerobic exercise training.

Treatment:

Behavioral: Dietary Approach