Effects of Topical Gentamicin on the Prevention of Peritoneal Dialysis Related Infection

Phramongkutklao College of Medicine and Hospital

Status: Unknown

Conditions: Peritoneal Dialysis-related Infection

Treatments: Drug: Mupirocin; Drug: Gentamicin

Study type: Interventional

Funder types: Other

Identifiers

NCT05251584

PDRI-2021

Details and patient eligibility

About

Peritoneal dialysis-related infection is a complication that leads to peritoneal dialysis catheter removal or patient death. The present study aimed to investigate peritoneal dialysis-related infection, causative pathogens resulting in topical 2% mupirocin ointments period compare with 0.1% gentamicin cream period. Rate of catheter removal, time to first peritoneal dialysis-related infection after apply gentamicin cream.

Enrollment: 60 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age greater than or equal to 20 years
• End stage renal disease patients on peritoneal dialysis follow up at Phramongkutklao hospital's peritoneal dialysis clinic between January 1, 2021 to March 31, 2023
• Start peritoneal dialysis or follow up at Phramongkutklao hospital's peritoneal dialysis clinic at least 90 days before recruited
• Use topical mupirocin ointment for prevention of peritoneal dialysis-related infection between January 1, 2021 to December 31, 2021
• Can be used LINE application throughout the study

Exclusion criteria

• Allergy to gentamicin or components
• Previous systemic antibiotics use within 90 days before recruited
• Previous peritoneal dialysis-related infection within 28 days before recruited
• Immunosuppressants used
• Prospective follow up less than 2 months
• Don't sign informed consent

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

Mupirocin and Gentamicin

Experimental group

Description:

2% mupirocin ointments apply at exit-site once daily after wound cleaning before recruit in the study then use 0.1% gentamicin cream apply at exit-site once daily after wound cleaning after entry to the study.

Treatment:

Drug: Gentamicin

Drug: Mupirocin