Effects of Topical Local Anesthesia of Pulmonary Vein Combined With Vagus Nerve Block on the Incidence of Atrial Fibrillation After Thoracic Surgery

Han Yuan

Status: Unknown

Conditions: Atrial Fibrillation

Treatments: Procedure: topical local anesthesia of pulmonary vein combined with vagus nerve block

Study type: Interventional

Funder types: Other

Identifiers

NCT03919786

XYFY2019-KL002-02

Details and patient eligibility

About

This study intends to explore a new therapy to reduce the incidence of atrial fibrillation in thoracic patient who receive video-assisted thoracoscopic lobectomy .The results of the study are to assess the effects of this new intervention on the incidence，duration of atrial fibrillation and other complications including postoperative delirium after video-assisted thoracoscopic lobectomy .And reducing the burden of POAF on patients and their families, hospitals and public resources.

Enrollment: 150 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Thoracoscopic lobectomy and bilobectomy
• ASA class I-III
• Age is greater than or equal to 50 years old
• Han Nationality, mother tongue is chinese
• The people signed informed consent

Exclusion criteria

• history of chronic atrial arrhythmia
• sick sinus syndrome
• history of second-degree atrioventricular block
• taking class I or class III antiarrhythmic drugs or β-receptor blocker
• history of radiofrequency ablation
• hyperthyroidism
• contraindications of ropivacaine, lidocaine
• pregnancy and lactation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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150 participants in 2 patient groups, including a placebo group

intervention group

Experimental group

Description:

Durg：0.375% Ropivacaine and 1% lidocaine topical local anesthesia of pulmonary vein with lidocaine+ropivacaine at the beginning and the end of surgery operation. Block vagus nerve with lidocaine+ropivacaine 1ml after exposing the pleural apex

Treatment:

Procedure: topical local anesthesia of pulmonary vein combined with vagus nerve block

normal saline group

Placebo Comparator group

Description:

Same volume of normal saline will be administrated

Treatment:

Procedure: topical local anesthesia of pulmonary vein combined with vagus nerve block