Effects of Topical Local Anesthesia of Pulmonary Vein Combined With Vagus Nerve Block on the Incidence of Atrial Fibrillation After Thoracic Surgery

H

Han Yuan

Status

Unknown

Conditions

Atrial Fibrillation

Treatments

Procedure: topical local anesthesia of pulmonary vein combined with vagus nerve block

Study type

Interventional

Funder types

Other

Identifiers

NCT03919786
XYFY2019-KL002-02

Details and patient eligibility

About

This study intends to explore a new therapy to reduce the incidence of atrial fibrillation in thoracic patient who receive video-assisted thoracoscopic lobectomy .The results of the study are to assess the effects of this new intervention on the incidence,duration of atrial fibrillation and other complications including postoperative delirium after video-assisted thoracoscopic lobectomy .And reducing the burden of POAF on patients and their families, hospitals and public resources.

Enrollment

150 estimated patients

Sex

All

Ages

50+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Thoracoscopic lobectomy and bilobectomy
  • ASA class I-III
  • Age is greater than or equal to 50 years old
  • Han Nationality, mother tongue is chinese
  • The people signed informed consent

Exclusion criteria

  • history of chronic atrial arrhythmia
  • sick sinus syndrome
  • history of second-degree atrioventricular block
  • taking class I or class III antiarrhythmic drugs or β-receptor blocker
  • history of radiofrequency ablation
  • hyperthyroidism
  • contraindications of ropivacaine, lidocaine
  • pregnancy and lactation

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

150 participants in 2 patient groups, including a placebo group

intervention group
Experimental group
Description:
Durg:0.375% Ropivacaine and 1% lidocaine topical local anesthesia of pulmonary vein with lidocaine+ropivacaine at the beginning and the end of surgery operation. Block vagus nerve with lidocaine+ropivacaine 1ml after exposing the pleural apex
Treatment:
Procedure: topical local anesthesia of pulmonary vein combined with vagus nerve block
normal saline group
Placebo Comparator group
Description:
Same volume of normal saline will be administrated
Treatment:
Procedure: topical local anesthesia of pulmonary vein combined with vagus nerve block

Trial contacts and locations

1

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Central trial contact

Junli Cao

Data sourced from clinicaltrials.gov

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